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副软海绵素X和Y，来自软珊瑚的新型抗菌倍半萜类化合物

Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral .

作者信息

Elshamy Abdelsamed I, Mohamed Tarik A, Elkady Eman M, Saleh Ibrahim A, El-Beih Ahmed A, Alhammady Montaser A, Ohta Shinji, Umeyama Akemi, Paré Paul W, Hegazy Mohamed-Elamir F

机构信息

Department of Natural Compounds Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.

Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.

出版信息

Antibiotics (Basel). 2021 Sep 24;10(10):1158. doi: 10.3390/antibiotics10101158.

DOI:10.3390/antibiotics10101158
PMID:34680740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8532672/
Abstract

The organic extracts of the Red Sea soft coral has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (, ). In addition to these newly characterized compounds, ten known metabolites (-) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (-) against , , and . Compound showed antimicrobial activity against all assayed microorganisms.

摘要

红海软珊瑚的有机提取物已鉴定出两种新榄烷型倍半萜

副榄醇X和Y（，）。除了这些新鉴定的化合物外，还分离出了十种已知的代谢物（-）。先前报道的化合物通过光谱数据（一维和二维核磁共振以及质谱数据）的文献比较得以阐明。研究了化合物（-）对、、和的体外抗菌活性。化合物对所有检测的微生物均显示出抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/cfcafcf3a145/antibiotics-10-01158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/8f2c9affcc26/antibiotics-10-01158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/9b90f5c60396/antibiotics-10-01158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/cfcafcf3a145/antibiotics-10-01158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/8f2c9affcc26/antibiotics-10-01158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/9b90f5c60396/antibiotics-10-01158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc8/8532672/cfcafcf3a145/antibiotics-10-01158-g003.jpg

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