来自软珊瑚聚伞柳珊瑚的新倍半萜类化合物——副柳珊瑚素J - P

Paralemnolins J-P, new sesquiterpenoids from the soft coral Paralemnalia thyrsoide.

作者信息

Wang Guey-Horng, Huang Ho-Cheng, Su Jui-Hsin, Wu Yang-Chang, Sheu Jyh-Horng

机构信息

Department of Cosmetic Science, Chia-Nan University of Pharmacy and Science, Taiwan.

出版信息

Chem Pharm Bull (Tokyo). 2010 Jan;58(1):30-3. doi: 10.1248/cpb.58.30.

DOI:10.1248/cpb.58.30

PMID:20045962

Abstract

Six new sesquiterpenoids, paralemnolins J-O (1-6), along with one novel norsesquiterpenoid, paralemnolin P (7), have been isolated from the soft coral Paralemnalia thyrsoides. The structures of metabolites 1-7 were established on the basis of extensive NMR study and chemical methods. The structure of 5 was further confirmed by a single-crystal X-ray analysis. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is described.

摘要

从软珊瑚Thyrsoides Paralemnalia中分离出了6种新的倍半萜类化合物，paralemnolins J - O（1 - 6），以及一种新的降倍半萜类化合物，paralemolin P（7）。基于广泛的核磁共振研究和化学方法确定了代谢产物1 - 7的结构。通过单晶X射线分析进一步证实了化合物5的结构。还描述了这些代谢产物对一组有限的癌细胞系的细胞毒性。