Department of Geriatrics, Peking University First Hospital, Beijing, China.
Arch Med Sci. 2012 Jul 4;8(3):471-6. doi: 10.5114/aoms.2012.29402.
The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-γ (PPAR-γ) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).
We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-γ receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.
The concentration of PPAR-γ receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-α were higher than those in the control group (all p < 0.01). The PPAR-γ level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-γ, hs-CRP, TNF-α and LAD level were associated with AF.
Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-γ receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-γ may take part in the pathogenesis of AF.
本研究旨在探讨老年心房颤动（AF）患者血清过氧化物酶体增殖物激活受体-γ（PPAR-γ）蛋白浓度与炎症标志物之间的关系。
共纳入 73 例老年患者：45 例为 AF 患者（试验组），28 例窦性心律患者（对照组）。检测血清 PPAR-γ 受体蛋白、高敏 C 反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。研究方案和书面知情同意书均获得北京大学第一医院临床研究伦理委员会批准。
AF 患者的 PPAR-γ 受体蛋白浓度低于对照组（p<0.01），hs-CRP、IL-6 和 TNF-α 浓度均高于对照组（均 p<0.01）。PPAR-γ 水平与 hs-CRP、IL-6 和左心房直径（LAD）水平呈负相关（均 p<0.05）。Logistic 回归分析显示，PPAR-γ、hs-CRP、TNF-α 和 LAD 水平与 AF 相关。
老年 AF 患者存在炎症状态和心房重构。AF 中 PPAR-γ 受体蛋白浓度与炎症呈负相关。作为调节炎症基因表达的重要转录因子，PPAR-γ 可能参与 AF 的发病机制。
