Sadimin Evita T, Foran David J
Department of Pathology, Robert Wood Johnson Medical School, New Brunswick, NJ.
N Am J Med Sci (Boston). 2012 Apr;5(2):103-109. doi: 10.7156/v5i2p103.
Pathologists routinely interpret gross and microscopic specimens to render diagnoses and to engage in a broad spectrum of investigative research. Multiple studies have demonstrated that imaging technologies have progressed to a level at which properly digitized specimens provide sufficient quality comparable to the traditional glass slides examinations. Continued advancements in this area will have a profound impact on the manner in which pathology is conducted from this point on. Several leading institutions have already undertaken ambitious projects directed toward digitally imaging, archiving, and sharing pathology specimens. As a result of these advances, the use of informatics in diagnostic and investigative pathology applications is expanding rapidly. In addition, the advent of novel technologies such as multispectral imaging makes it possible to visualize and analyze imaged specimens using multiple wavelengths simultaneously. As these powerful technologies become increasingly accepted and adopted, the opportunities for gaining new insight into the underlying mechanisms of diseases as well as the potential for discriminating among subtypes of pathologies are growing accordingly.
病理学家通常通过解读大体标本和显微镜标本进行诊断，并开展广泛的调查研究。多项研究表明，成像技术已发展到一定水平，经过适当数字化处理的标本所提供的质量足以与传统玻璃切片检查相媲美。这一领域的持续进步将对从现在起病理学的开展方式产生深远影响。几家领先机构已经开展了雄心勃勃的项目，旨在对病理标本进行数字成像、存档和共享。由于这些进展，信息学在诊断和研究性病理学应用中的使用正在迅速扩大。此外，多光谱成像等新技术的出现，使得同时使用多个波长对成像标本进行可视化和分析成为可能。随着这些强大技术越来越被接受和采用，深入了解疾病潜在机制的机会以及区分不同病理亚型的潜力也相应增加。
