微小 RNA 与癌症治疗和预后。
MicroRNAs in cancer treatment and prognosis.
出版信息
Am J Cancer Res. 2012;2(4):414-33. Epub 2012 Jun 28.
Abstract
Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.
摘要
表观遗传改变和基因突变引起的 microRNA 表达紊乱不仅可能促进肿瘤发生，还可能促进肿瘤的侵袭、转移、耐药性以及对化疗和放疗的抵抗。一些研究已经对正常组织和肿瘤组织中的 microRNA 表达进行了分析，结果表明存在独特的 microRNA 特征，可作为癌症诊断和预后的标志物。本文讨论了 microRNAs 作为参与癌症的调节生物分子的重要性，重点介绍了与癌症侵袭、转移、表观遗传改变、化疗耐药性和放疗耐药性相关的 microRNAs。鉴定肿瘤中差异表达的 microRNAs 及其靶基因为基因治疗提供了新的工具；重新表达因癌症发生而沉默的 microRNAs 或沉默致癌 microRNAs 可有效阻断与癌症相关的细胞增殖。
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本文引用的文献
1
MicroRNAs and stem cells: control of pluripotency, reprogramming, and lineage commitment.微小 RNA 与干细胞：多能性、重编程和谱系分化的调控。
Circ Res. 2012 Mar 30;110(7):1014-22. doi: 10.1161/CIRCRESAHA.111.243394.
2
Interactions between cancer stem cells and their niche govern metastatic colonization.癌症干细胞与其生态位之间的相互作用控制着转移定植。
Nature. 2011 Dec 7;481(7379):85-9. doi: 10.1038/nature10694.
3
MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells.显微切割的正常食管鳞状上皮和肿瘤细胞的微小RNA分析
Am J Cancer Res. 2011;1(5):574-584.
4
MicroRNA in lung cancer diagnostics and treatment.肺癌诊断和治疗中的 microRNA。
Mutat Res. 2011 Dec 1;717(1-2):25-31. doi: 10.1016/j.mrfmmm.2011.04.002. Epub 2011 Apr 20.
5
The Aicardi-Goutières syndrome. Molecular and clinical features of RNAse deficiency and microRNA overload.Aicardi-Goutières 综合征。RNA 酶缺陷和 microRNA 过载的分子和临床特征。
Mutat Res. 2011 Dec 1;717(1-2):99-108. doi: 10.1016/j.mrfmmm.2011.03.018. Epub 2011 Apr 15.
6
Extracellular microRNA: a new source of biomarkers.细胞外 microRNA：一种新的生物标志物来源。
Mutat Res. 2011 Dec 1;717(1-2):85-90. doi: 10.1016/j.mrfmmm.2011.03.004. Epub 2011 Mar 23.
7
Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung.香烟烟雾诱导的小鼠肺部 microRNA 表达改变的剂量反应和持久性。
Mutat Res. 2011 Dec 1;717(1-2):9-16. doi: 10.1016/j.mrfmmm.2010.12.008. Epub 2010 Dec 24.
8
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Mol Cancer. 2010 Dec 20;9:317. doi: 10.1186/1476-4598-9-317.
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Oncogene. 2011 Mar 3;30(9):1082-97. doi: 10.1038/onc.2010.487. Epub 2010 Nov 8.
10
Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.在定义小鼠肺部的 microRNA 图谱中，组织病理学改变、香烟烟雾和化学预防剂之间的相互作用。
Mutat Res. 2011 Dec 1;717(1-2):17-24. doi: 10.1016/j.mrfmmm.2010.10.003. Epub 2010 Oct 23.
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