École de psychologie, Université Laval, Québec, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, Université Laval, Québec, Canada.
Psychiatry Res. 2012 Dec 30;200(2-3):159-66. doi: 10.1016/j.psychres.2012.06.008. Epub 2012 Aug 3.
Time perception (TP) impairment in schizophrenia has been originally described by clinicians and afterwards addressed in laboratory. Previous studies generally observed that schizophrenia patients overestimate time and that their timing sensitivity is impaired. However, because of the disease cognitive impairments, no study until now allows to draw definitive conclusions about the nature of TP disturbances. The aim of this study is to isolate a genuine TP disorder in schizophrenia, i.e., a disorder that would be related to the functioning of an internal clock. The main hypothesis tested is that patients' internal clock runs faster than that of healthy controls. Twenty-five patients suffering from a first-episode of schizophrenia and twenty-five healthy controls performed an innovative task called method of dynamic stimuli, designed to measure the natural frequency (F(n)) of the internal clock, concomitant with a neuropsychological assessment. We observed no significant difference in F(n) between groups. Compared to controls, there was a marginally higher variability in time reproduction in patients. Patients' pattern of results and significant correlations between TP tasks and memory outcomes suggest that TP impairments are related to memory impairment in schizophrenia. These conclusions are supported by a growing literature showing that cognition is involved in TP in schizophrenia.
时间感知（TP）障碍在精神分裂症中最初由临床医生描述，随后在实验室中进行了研究。先前的研究普遍观察到精神分裂症患者高估时间，且他们的时间敏感性受损。然而，由于疾病认知障碍，到目前为止，没有研究能够对 TP 障碍的性质得出明确的结论。本研究旨在在精神分裂症中分离出真正的 TP 障碍，即与内部时钟功能相关的障碍。主要测试的假设是患者的内部时钟比健康对照组的运行速度更快。25 名首发精神分裂症患者和 25 名健康对照者进行了一项名为动态刺激法的创新任务，旨在测量内部时钟的自然频率（F(n)），同时进行神经心理学评估。我们未观察到组间 F(n) 有显著差异。与对照组相比，患者在时间再现方面的可变性略高。患者的结果模式以及 TP 任务与记忆结果之间的显著相关性表明，TP 障碍与精神分裂症中的记忆障碍有关。这些结论得到了越来越多的文献的支持，这些文献表明认知在精神分裂症中的 TP 中起作用。
