Izmir Bozyaka Research Hospital, Kadın Dogum Klinigi, Bozyaka, Izmir, Turkey.
Arch Gynecol Obstet. 2012 Dec;286(6):1473-6. doi: 10.1007/s00404-012-2494-0. Epub 2012 Aug 4.
The liver-derived Fetuin-A (α2-Heremans Schmid glycoprotein) is a circulating glycoprotein that may be related to insulin resistance and polycystic ovary syndrome (PCOS). We aimed to investigate the Fetuin-A levels in patients with PCOS.
A total of 88 women were included in the study. We measured the Fetuin-A levels in 44 women with PCOS and compared with 44 healthy women.
The mean age in control group was 28.61±5.0 (18-38) and 25.5±4.1 (17-36) in PCOS group. While there was statistically significant difference in terms of age and testosterone levels, there was no difference in terms of smoking status and BMI between the groups. Accordingly, women with PCOS were older than controls [28.61±5.0 (18-38) and 25.5±4.1 (17-36), respectively, p=0.002]. The mean Fetuin-A level of PCOS group was 255.4±37.2 (203.1-388.9) ng/mL and the mean Fetuin-A level of control group was 253.0±43.2 (179.9-355.4) ng/mL. There was no difference between the groups with regard to Fetuin-A, before and after adjustment for age (p values 0.780 and 0.835, respectively).
Serum Fetuin-A levels of women with PCOS did not change in comparison with the healthy controls.
肝脏来源的胎球蛋白-A（α2-赫尔曼斯施密特糖蛋白）是一种循环糖蛋白，可能与胰岛素抵抗和多囊卵巢综合征（PCOS）有关。我们旨在研究 PCOS 患者的胎球蛋白-A 水平。
本研究共纳入 88 名女性。我们测量了 44 名 PCOS 患者和 44 名健康女性的胎球蛋白-A 水平，并进行了比较。
对照组的平均年龄为 28.61±5.0（18-38）岁，PCOS 组为 25.5±4.1（17-36）岁。虽然年龄和睾酮水平存在统计学差异，但两组的吸烟状况和 BMI 无差异。因此，PCOS 患者比对照组年龄更大[分别为 28.61±5.0（18-38）和 25.5±4.1（17-36），p=0.002]。PCOS 组的胎球蛋白-A 平均水平为 255.4±37.2（203.1-388.9）ng/mL，对照组的胎球蛋白-A 平均水平为 253.0±43.2（179.9-355.4）ng/mL。两组之间的胎球蛋白-A 水平没有差异，在调整年龄后也是如此（p 值分别为 0.780 和 0.835）。
与健康对照组相比，PCOS 患者的血清胎球蛋白-A 水平没有变化。
