Department of Anesthesiology and Pain Medicine, School of Medicine, Hallym University, Chuncheon 200-704, Korea.
Yonsei Med J. 2012 Sep;53(5):1010-3. doi: 10.3349/ymj.2012.53.5.1010.
This prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty.
Sixty patients undergoing myringoplasty were sedated with midazolam in the presence of remifentanil (group MR), or after saline injection instead of remifentanil (group M).
Three patients (10%) in group M complained of nausea; two vomited. Four patients (13%) in group MR complained of nausea and vomited within 24 h after surgery. Rescue drugs were given to the six patients who vomited. No significant difference was detected between the two groups regarding the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.
Midazolam-based continuous sedation can reduce PONV after myringoplasty. Compared with midazolam alone, midazolam with remifentanil produced no difference in the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.
本前瞻性研究评估了咪达唑仑联合或不联合瑞芬太尼持续镇静对鼓室成形术患者术后恶心呕吐（PONV）的影响。
60 例行鼓室成形术的患者在咪达唑仑存在瑞芬太尼的情况下镇静（MR 组），或在没有瑞芬太尼的情况下用生理盐水代替（M 组）。
M 组有 3 名（10%）患者诉恶心；2 名呕吐。MR 组有 4 名（13%）患者在手术后 24 小时内诉恶心并呕吐。对 6 名呕吐的患者给予了抢救药物。两组间恶心的发生率和严重程度、呕吐的发生率以及需要抢救药物的情况无显著差异。
咪达唑仑为基础的持续镇静可减少鼓室成形术后 PONV。与单用咪达唑仑相比，咪达唑仑联合瑞芬太尼在恶心的发生率和严重程度、呕吐的发生率或需要抢救药物方面没有差异。
