Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
Int J Toxicol. 2012 Jul-Aug;31(4 Suppl):77S-111S. doi: 10.1177/1091581812447202.
Cocamidopropyl betaine (CAPB) and related amidopropyl betaines are zwitterions used mainly as surfactants in cosmetics. These cosmetic ingredients are similar in their chemistry, in particular with respect to the presence of 3,3-dimethylamino-propylamine (DMAPA) and fatty acid amidopropyl dimethylamine (amidoamine) impurities, which are known as sensitizers. The CIR Expert Panel concluded that because these ingredients present no other significant toxicity, when formulated to be nonsensitizing (which may be based on a quantitative risk assessment), these ingredients are safe for use as cosmetic ingredients in the practices of use and concentration of this safety assessment.
椰油酰胺丙基甜菜碱（CAPB）和相关的酰胺丙基甜菜碱是两性离子，主要用作化妆品中的表面活性剂。这些化妆品成分在化学性质上相似，特别是在 3,3-二甲基氨基丙基胺（DMAPA）和脂肪酸酰胺丙基二甲胺（酰胺胺）杂质的存在方面，这些杂质是已知的敏化剂。CIR 专家小组得出结论，由于这些成分没有其他显著的毒性，当配方为非敏化剂（这可能基于定量风险评估）时，这些成分在使用和浓度的实践中作为化妆品成分使用是安全的。
