Pivarnik J M, Lee W, Miller J F, Werch J
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
Med Sci Sports Exerc. 1990 Dec;22(6):751-5. doi: 10.1249/00005768-199012000-00003.
The purpose of this investigation was to determine the effects of cycle exercise on maternal plasma volume (PV) and protein dynamics during pregnancy. Sixteen healthy gravidas (age = 23 +/- 4.6 yr) cycled for 5 min (75 W) at 4 wk intervals throughout term. Venous blood samples were drawn immediately prior to and during the last minute of exercise. Relative (percent) PV changes during exercise were calculated from hematocrit ratios and hemoglobin concentrations. Plasma was analyzed for total protein ([TP]) and albumin ([ALB]) concentrations and colloid osmotic pressure (COP). Resting blood volumes were also estimated (carbon monoxide rebreathing) so that absolute PV (ml) and TP and ALB contents (g) could be determined. COP increases (P less than 0.001) during exercise were similar at all gestational ages. Plasma volume, TP, and ALB decreased during exercise with significantly (P less than 0.001) greater losses occurring from 29-32 wk gestation. This may indicate an increase in capillary permeability to large molecules when vascular volume was highest.
本研究的目的是确定孕期进行周期性运动对母体血浆容量（PV）和蛋白质动力学的影响。16名健康孕妇（年龄 = 23 ± 4.6岁）在整个孕期每隔4周进行5分钟（75瓦）的骑行运动。在运动前及运动最后一分钟时采集静脉血样。根据血细胞比容比值和血红蛋白浓度计算运动期间相对（百分比）PV变化。分析血浆中的总蛋白（[TP]）、白蛋白（[ALB]）浓度及胶体渗透压（COP）。还估算静息血容量（一氧化碳再呼吸法），以便确定绝对PV（毫升）以及TP和ALB含量（克）。运动期间COP升高（P < 0.001）在所有孕周均相似。运动期间血浆容量、TP和ALB下降，在妊娠29 - 32周时损失显著更大（P < 0.001）。这可能表明当血管容量最高时，毛细血管对大分子的通透性增加。
