饮用水中的砷暴露会增加印度西孟加拉邦居民患肝脏和心血管疾病的风险。
Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India.
机构信息
Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S, C, Mullick Road, Kolkata, 700 032, India.
出版信息
BMC Public Health. 2012 Aug 10;12:639. doi: 10.1186/1471-2458-12-639.
BACKGROUND
Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India. Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.
METHODS
Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.
RESULTS
Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased in the arsenic exposed group.
CONCLUSIONS
Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and imparts increased cardiovascular risk.
背景
砷是一种天然饮用水污染物，影响印度西孟加拉邦的 2600 万人。慢性砷暴露会导致癌症、心血管疾病、肝病、神经病变和眼部疾病。本研究的目的是评估生物标志物，如肝酶水平，以评估肝细胞损伤；通过血清中抗核抗体（ANA）和抗双链 DNA 抗体的量来确定自身免疫状态；并预测砷暴露人群的心血管风险。
方法
通过肝功能试验确定慢性砷暴露对肝脏的影响。通过测量血清中的 ANA 和抗 dsDNA 来测量自身免疫状态。还测定了与心血管疾病风险增加相关的炎症细胞因子 IL6、IL8 和 MCP-1。
结果
我们的结果表明，砷暴露人群的血清胆红素、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶和 ANA 水平升高。砷暴露组的血清 IL6 和 IL8 水平也升高。
结论
慢性砷暴露会导致肝损伤，增加自身免疫标志物的血清水平，并增加心血管风险。
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