Bieglmayer Christian, Dimai Hans Peter, Gasser Rudolf Wolfgang, Kudlacek Stefan, Obermayer-Pietsch Barbara, Woloszczuk Wolfgang, Zwettler Elisabeth, Griesmacher Andrea
ÖQUASTA (Austrian Society for Quality Assurance and Standardization of Medical Laboratory Tests), 1090 Hörlgasse 18/5, Vienna, Austria.
Wien Med Wochenschr. 2012 Nov;162(21-22):464-77. doi: 10.1007/s10354-012-0133-9. Epub 2012 Aug 14.
Reasonable application of laboratory parameters in prevention, diagnosis, treatment and therapy monitoring of osteoporosis.
Physicians from different specialist disciplines (general medicine, geriatrics, gynaecology, urology, internal medicine-especially endocrinology and metabolism, nephrology, laboratory medicine, rheumatology, nuclear medicine, orthopaedics, paediatrics, rehabilitation and physical medicine, radiology, social medicine, transplantation medicine, accident surgery), moreover social insurances, hospitals and self-help groups.
Evaluation of aetiology of bone disorders, widening of the therapeutic spectrum for diseases of bone and knowledge on biochemical markers of bone turnover. Improvements in judging the success of therapy and in monitoring the compliance of patients. Research perspectives.
Scientific literature and guidelines, consensus meetings. RÉSUMÉ: Basic and specialized laboratory investigations are important in differentiation between primary and secondary osteoporosis for an adequate therapy. Biochemical markers of bone turnover are an additional aid in evaluation of individual fracture risk. These markers identify responders to bone therapy faster than surveillance of bone mineral density, which helps to improve patient's compliance too. Characteristics, preanalytic precautions and applications are presented for selected markers of bone resorption and formation and for parameters regulating bone metabolism.
合理应用实验室参数进行骨质疏松症的预防、诊断、治疗及治疗监测。
来自不同专科领域的医生（普通医学、老年医学、妇科、泌尿外科、内科——尤其是内分泌与代谢科、肾病科、检验医学、风湿病科、核医学、骨科、儿科、康复与物理医学、放射科、社会医学、移植医学、创伤外科），此外还有社会保险机构、医院及自助团体。
评估骨疾病的病因，拓宽骨疾病的治疗范围，了解骨转换的生化标志物。改进对治疗效果的判断及对患者依从性的监测。研究前景。
科学文献和指南、共识会议。
基础和专业实验室检查对于区分原发性和继发性骨质疏松症以进行适当治疗很重要。骨转换生化标志物有助于评估个体骨折风险。这些标志物比监测骨密度能更快地识别对骨治疗有反应者，这也有助于提高患者的依从性。文中介绍了所选骨吸收和形成标志物以及调节骨代谢参数的特点、分析前注意事项和应用。
