25 年糖尿病胃排空纵向评估。
A 25-year longitudinal evaluation of gastric emptying in diabetes.
机构信息
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
出版信息
Diabetes Care. 2012 Dec;35(12):2594-6. doi: 10.2337/dc12-0028. Epub 2012 Aug 13.
OBJECTIVE
To evaluate the natural history of gastric emptying in diabetes.
RESEARCH DESIGN AND METHODS
Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years.
RESULTS
There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17).
CONCLUSIONS
In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
目的
评估糖尿病患者胃排空的自然病程。
研究设计和方法
13 例糖尿病患者（12 例 1 型，1 例 2 型）在基线和 24.7±1.5 年后分别进行胃排空、血糖水平、糖化血红蛋白、上消化道症状和自主神经功能的测量。
结果
固体（100 分钟时的残留率）和液体（50%排空时间）胃排空均无变化（基线 58.5±5% vs. 随访 51.9±8%；P=0.35）和（基线 29.8±3 分钟 vs. 随访 34.3±6 分钟；P=0.37）。随访时固体胃排空与基线时胃排空相关（r=0.56，P<0.05）。随访时，血糖浓度降低（P=0.006），自主神经功能恶化（P=0.03），胃肠道症状保持不变（P=0.17）。
结论
在未选择的糖尿病患者中，胃排空在 25 年以上的时间内似乎非常稳定。
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