Quince Thelma A, Wood Diana F, Parker Richard A, Benson John
Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge, UK.
BMJ Open. 2012 Aug 13;2(4). doi: 10.1136/bmjopen-2012-001519. Print 2012.
To determine the prevalence of depression among male and female medical students, its change over time and whether depression persists for affected students.
Longitudinal study comprising annual questionnaire surveys which included the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D).
Between 2007 and 2010 all 1112 students entering the Core Science component (Year 1) and all 542 students entering the Clinical component (Year 4) of the Cambridge (UK) medical course were followed-up annually.
We analysed, separately for men and women, mean HADS-D scores, the proportions whose scores indicated depression at different time-points and for students maintaining participation, the number of occasions on which their HADS-D scores indicated depression.
725 Core Science and 364 Clinical students participated. Mean HADS-D scores ranged between 3.34 and 3.49 among all Core Science students and between 2.16 and 2.91 among all Clinical students. There was no difference between men and women in median HADS-D scores. Prevalence of depression ranged between 5.7% and 10.6% among all Core Science students and between 2.7% and 8.2% among all Clinical students. Over time Core Science students displayed no increase in mean HADS-D score. Among Clinical students only men displayed a small increase (time coefficient 0.33 (95% CI 0.11 to 0.55)). Prevalence did not increase over time. 220 Core Science and 150 Clinical students participated throughout the study. Of these, 18.2% and 10.6%, respectively, recorded HADS-D scores indicating depression on at least one occasion. Of 56 students recording depression at some point, 37 did so only once.
Prevalence of depression among participants was similar to that reported for comparable groups. Among men approaching the end of clinical studies depression scores increased. In all years a minority of students displayed depression; for some this persisted. Mechanisms are needed to identify and support students suffering from depression, particularly when persistent.
确定男女医学生中抑郁症的患病率、其随时间的变化情况以及抑郁症是否会在受影响的学生中持续存在。
纵向研究，包括年度问卷调查，其中包含医院焦虑抑郁量表（HADS-D）的抑郁分量表。
2007年至2010年期间，对英国剑桥医学课程基础科学部分（一年级）入学的所有1112名学生以及临床部分（四年级）入学的所有542名学生进行了年度随访。
我们分别对男性和女性的HADS-D平均得分、在不同时间点得分表明患有抑郁症的比例进行了分析，对于持续参与研究的学生，还分析了其HADS-D得分表明患有抑郁症的次数。
725名基础科学学生和364名临床学生参与了研究。所有基础科学学生的HADS-D平均得分在3.34至3.49之间，所有临床学生的HADS-D平均得分在2.16至2.91之间。男性和女性的HADS-D中位数得分没有差异。所有基础科学学生中抑郁症的患病率在5.7%至10.6%之间，所有临床学生中抑郁症的患病率在2.7%至8.2%之间。随着时间的推移，基础科学学生的HADS-D平均得分没有增加。在临床学生中，只有男性有小幅增加（时间系数为0.33（95%置信区间为0.11至0.55））。患病率没有随时间增加。220名基础科学学生和150名临床学生全程参与了研究。其中，分别有18.2%和10.6%的学生至少有一次HADS-D得分表明患有抑郁症。在56名曾在某些时候记录有抑郁症的学生中，37名学生仅出现过一次。
参与者中抑郁症的患病率与可比群体报告的患病率相似。临近临床学习结束时，男性的抑郁得分有所增加。在所有年份中，少数学生表现出抑郁症；对一些学生来说，这种情况持续存在。需要建立机制来识别和支持患有抑郁症的学生，尤其是那些抑郁症持续存在的学生。
