Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
Eur J Clin Microbiol Infect Dis. 2012 Dec;31(12):3265-79. doi: 10.1007/s10096-012-1716-5. Epub 2012 Aug 16.
Swine flu is a respiratory disease caused by influenza A H1N1 virus. The current pandemic of swine flu is most probably due to a mutation-more specifically, a re-assortment of four known strains of influenza A virus subtype H1N1. Antigenic variation of influenza viruses while circulating in the population is an important factor leading to difficulties in controlling influenza by vaccination. Due to the global effect of swine flu and its effect on humans, extensive investigations are being undertaken. In this context, Tamiflu is the only available drug used in the prophylaxis of this disease and is made from the compound shikimic acid. Due to the sudden increase in the demand of shikimic acid, its price has increased greatly. Thus, it is necessary to find an alternative approach for the treatment of swine flu. This review presents the overall information of swine flu, beginning from its emergence to the prevention and treatment of the disease, with a major emphasis on the alternative approach (bacterial fermentation process) for the treatment of swine flu. The alternative approach for the treatment of swine flu includes the production of shikimic acid from a fermentation process and it can be produced in large quantities without any time limitations.
猪流感是由甲型 H1N1 流感病毒引起的呼吸道疾病。当前的猪流感大流行很可能是由于一种突变——更具体地说，是四种已知的甲型 H1N1 流感病毒亚型的重组。流感病毒在人群中传播时的抗原变异是导致通过疫苗接种控制流感困难的一个重要因素。由于猪流感的全球影响及其对人类的影响，正在进行广泛的调查。在这种情况下，达菲是预防这种疾病唯一可用的药物，它是由莽草酸制成的。由于莽草酸的需求突然增加，其价格大幅上涨。因此，有必要寻找一种替代方法来治疗猪流感。本文综述了猪流感的整体信息，从其出现到疾病的预防和治疗，重点介绍了治疗猪流感的替代方法（细菌发酵工艺）。治疗猪流感的替代方法包括通过发酵过程生产莽草酸，并且可以在没有任何时间限制的情况下大量生产。
