State Research Center of Virology and Biotechnology VECTOR, Novosibirsk, Russia.
Arch Virol. 2012 Dec;157(12):2335-41. doi: 10.1007/s00705-012-1442-4. Epub 2012 Aug 19.
Before 2008, HIV-1 subtype A was the predominant genetic variant in the Novosibirsk oblast of Russia as well as in most parts of this country. However, a rapid spread of the recombinant HIV-1 02_AG form has been reported in Novosibirsk since 2009. We have analyzed the genome of the 10.RU.6637 isolate, a HIV-1 02_AG recombinant form, which represents a monophyletic cluster of the HIV-1 variants widespread in this region. Phylogenetic analysis has shown that the Siberian 10.RU.6637 isolate displays the highest sequence identity to the HIV-1 subtype AG forms circulating in Uzbekistan. However, recombination analysis of 10.RU.6637 has demonstrated that this isolate is a recombinant form between HIV-1 subtype A and CRF02_AG, differing in its genetic structure from both the CRF02_AG reference sequences and the Central Asian variants of HIV-1 02_AG.
2008 年以前，HIV-1 亚型 A 是俄罗斯新西伯利亚地区以及该国大部分地区的主要遗传变异体。然而，自 2009 年以来，新西伯利亚报告了 HIV-1 02_AG 重组形式的快速传播。我们分析了 10.RU.6637 分离株的基因组，这是一种 HIV-1 02_AG 重组形式，代表了该地区广泛传播的 HIV-1 变体的单系聚类。系统发育分析表明，西伯利亚 10.RU.6637 分离株与在乌兹别克斯坦流行的 HIV-1 亚型 AG 形式具有最高的序列同一性。然而，对 10.RU.6637 的重组分析表明，该分离株是 HIV-1 亚型 A 和 CRF02_AG 之间的重组形式，其遗传结构与 CRF02_AG 参考序列和 HIV-1 02_AG 的中亚变体均不同。
