Department of Parasitology, Shandong University School of Medicine, Jinan, Shandong, China.
Hum Vaccin Immunother. 2012 Sep;8(9):1305-8. doi: 10.4161/hv.21006. Epub 2012 Aug 21.
Toxoplasma gondii is a ubiquitous protozoan parasite that can infect a wide range of animals including humans. This single known species in the genus Toxoplasma is considered as one of the most successful eukaryotic pathogens which is of major medical and veterinary importance. Effective vaccines may contribute toward preventing and controlling the spread of toxoplasmosis. The present communication addresses the current status of development of vaccines against T. gondii. Further discussion is made on the difficulties along with challenges, such as vaccine construct, mode of vaccine administration and standardization of immunization evaluation. Finally suggestions are made on possible directions for future research on the development of vaccines against T. gondii.
刚地弓形虫是一种广泛存在的原生动物寄生虫，可感染包括人类在内的多种动物。在刚地弓形虫属中，这唯一已知的物种被认为是最成功的真核病原体之一，具有重要的医学和兽医意义。有效的疫苗可能有助于预防和控制弓形体病的传播。本通讯介绍了目前针对刚地弓形虫的疫苗开发状况。进一步讨论了疫苗构建、疫苗接种方式和免疫评估标准化等方面的困难和挑战。最后，就刚地弓形虫疫苗开发的未来研究方向提出了建议。
