Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA.
Angew Chem Int Ed Engl. 2012 Sep 17;51(38):9562-6. doi: 10.1002/anie.201205137. Epub 2012 Aug 22.
We have developed a mild aerobic oxidation protocol using visible light photocatalysis to synthesize structurally diverse -arylindoles. The procedure employs 4 mol% Ru(bpz), 18W LED light, and is performed open to the atmosphere. Readily prepared -stryryl anilines are converted to a variety of indoles via a cascade sequence composed of oxidation of anilines, C-N bond formation, and aromatization. A 1,2-carbon shift can be also incorporated into this cascade event to further extend the substrate scope of the method. bpz = 2, 2′-Bipyrazine
我们开发了一种使用可见光光催化的温和有氧氧化方案，用于合成结构多样的 -芳基吲哚。该方法采用 4 mol% [Ru(bpz)] (PF)、18W LED 灯，并在开放的大气条件下进行。通过苯胺氧化、C-N 键形成和芳构化组成的级联序列，很容易制备的 -苯乙烯基苯胺转化为各种吲哚。该级联反应还可以进一步整合 1,2-碳迁移，从而进一步扩展该方法的底物范围。bpz = 2,2′-联吡嗪
