Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia, USA.
J Virol. 2012 Nov;86(21):11931-4. doi: 10.1128/JVI.01349-12. Epub 2012 Aug 22.
Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen. Studies with a catalase inhibitor indicated that virus-associated catalase can have a role in protecting the virus from oxidative inactivation. HSV-1 was found to be more sensitive to killing by hydrogen peroxide in the presence of a catalase inhibitor than in its absence. The results suggest a protective role for catalase during the time HSV-1 spends in the oxidizing environment outside a host cell.
单纯疱疹病毒 1（HSV-1）被证明含有过氧化氢酶，这种酶能够将过氧化氢转化为水和氧气，从而解毒。使用过氧化氢酶抑制剂的研究表明，与病毒相关的过氧化氢酶在保护病毒免受氧化失活方面可能发挥作用。与不存在过氧化氢酶抑制剂的情况相比，HSV-1 在存在过氧化氢酶抑制剂的情况下对过氧化氢的杀伤更为敏感。这些结果表明，在 HSV-1 处于宿主细胞外氧化环境中的时候，过氧化氢酶发挥了保护作用。
