1. School of Medicine, Stanford University, Stanford, CA, 94305, USA;
Theranostics. 2012;2(8):801-14. doi: 10.7150/thno.4419. Epub 2012 Aug 16.
Cardiovascular disease is the leading cause of death worldwide and is often associated with partial or full occlusion of the blood vessel network in the affected organs. Restoring blood supply is critical for the successful treatment of cardiovascular diseases. Therapeutic angiogenesis provides a valuable tool for treating cardiovascular diseases by stimulating the growth of new blood vessels from pre-existing vessels. In this review, we discuss strategies developed for therapeutic angiogenesis using single or combinations of biological signals, cells and polymeric biomaterials. Compared to direct delivery of growth factors or cells alone, polymeric biomaterials provide a three-dimensional drug-releasing depot that is capable of facilitating temporally and spatially controlled release. Biomimetic signals can also be incorporated into polymeric scaffolds to allow environmentally-responsive or cell-triggered release of biological signals for targeted angiogenesis. Recent progress in exploiting genetically engineered stem cells and endogenous cell homing mechanisms for therapeutic angiogenesis is also discussed.
心血管疾病是全球范围内的主要死亡原因，通常与受影响器官的血管网络部分或完全阻塞有关。恢复血液供应对于成功治疗心血管疾病至关重要。治疗性血管生成通过刺激新血管从预先存在的血管生长，为治疗心血管疾病提供了有价值的工具。在这篇综述中，我们讨论了使用单一或组合的生物信号、细胞和聚合物生物材料开发的治疗性血管生成策略。与单独直接输送生长因子或细胞相比，聚合物生物材料提供了一个三维药物释放库，能够促进时间和空间上的控制释放。仿生信号也可以被整合到聚合物支架中，以允许环境响应或细胞触发的生物信号释放，用于靶向血管生成。还讨论了利用基因工程干细胞和内源性细胞归巢机制进行治疗性血管生成的最新进展。
