Epidemiology and Public Health Group, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom.
PLoS One. 2012;7(8):e43378. doi: 10.1371/journal.pone.0043378. Epub 2012 Aug 15.
Bisphenol A is widely used in food and drinks packaging. There is evidence of associations between raised urinary bisphenol A (uBPA) and increased incidence of reported cardiovascular diagnoses.
METHODOLOGY/PRINCIPAL FINDINGS: To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. Linear models were adjusted for BMI, occupational social class and diabetes status. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n=86) and 120 had normal coronary arteries. The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD=5.96 ng/ml OR=1.43, CI 1.03 to 1.98, p=0.033), and near significant for intermediate disease (OR=1.69, CI 0.98 to 2.94, p=0.061). There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined.
CONCLUSIONS/SIGNIFICANCE: BPA exposure was higher in those with severe coronary artery stenoses compared to those with no vessel disease. Larger studies are needed to estimate true dose response relationships. The mechanisms underlying the association remain to be established.
双酚 A 广泛用于食品和饮料包装。有证据表明，尿液中双酚 A（uBPA）水平升高与心血管疾病报告发病率增加有关。
方法/主要发现：为了评估双酚 A 暴露与血管造影分级冠状动脉粥样硬化之间的关联，我们对英国剑桥郡的代谢组学和基因组学在冠状动脉疾病（MaGiCAD）研究中的 591 名患者进行了研究，将尿液中的双酚 A（uBPA）与冠状动脉疾病（CAD）的严重程度分级进行了比较。线性模型调整了 BMI、职业社会阶层和糖尿病状况。385 例患者存在严重（一至三血管）CAD，86 例患者存在中度疾病（n=86），120 例患者存在正常冠状动脉。正常冠状动脉患者的 uBPA 中位数浓度为 1.28ng/ml，严重 CAD 患者为 1.53ng/ml。与正常冠状动脉患者相比，严重 CAD 患者的 uBPA 浓度明显更高（每 uBPA 标准差的 OR=5.96ng/ml OR=1.43，95%CI 1.03 至 1.98，p=0.033），中度疾病患者的 OR 接近显著（OR=1.69，95%CI 0.98 至 2.94，p=0.061）。严重 CAD（需要手术）患者与其他组之间的 uBPA 无显著差异。
结论/意义：与无血管疾病患者相比，严重冠状动脉狭窄患者的双酚 A 暴露水平更高。需要更大的研究来估计真实的剂量反应关系。关联的潜在机制仍有待确定。
