Amyes S G, Doherty C J, Young H K
Eur J Clin Microbiol. 1986 Jun;5(3):287-91. doi: 10.1007/BF02017783.
The results of a three year evaluation of the incidence and type of trimethoprim resistance in pathogens responsible for significant bacteriuria in a general hospital in Edinburgh UK, are presented and compared to results of a previous study. In the present study, trimethoprim resistance was 50% more frequent in bacteria isolated from men and nearly twice as frequent in bacteria from elderly patients. However, the proportion of trimethoprim resistant strains fell annually when resistance was measured at trimethoprim concentrations of both 10 mg/l and 1000 mg/l. The proportion of strains able to transfer trimethoprim resistance also fell by half, and there was some movement of trimethoprim resistance transposons into the bacterial chromosome. These results suggest that migration of high-level trimethoprim resistance genes into the permanent location of the bacterial chromosome is occurring.
本文呈现了对英国爱丁堡一家综合医院中导致严重菌尿的病原体进行的为期三年的甲氧苄啶耐药性发生率及类型的评估结果，并与之前一项研究的结果进行了比较。在本研究中，从男性分离出的细菌中，甲氧苄啶耐药性的出现频率高出50%，而在老年患者的细菌中，该耐药性出现频率几乎高出一倍。然而，当分别在甲氧苄啶浓度为10mg/l和1000mg/l时测定耐药性，每年甲氧苄啶耐药菌株的比例都在下降。能够转移甲氧苄啶耐药性的菌株比例也下降了一半，并且有一些甲氧苄啶耐药转座子转移到了细菌染色体中。这些结果表明，高水平甲氧苄啶耐药基因正在迁移到细菌染色体的固定位置。
