Cameron Todd A, Zambryski Patricia C
Chem Biol. 2012 Aug 24;19(8):934-6. doi: 10.1016/j.chembiol.2012.08.002.
With common bacterial pathogens becoming increasingly resistant to the current therapeutic arsenal, there is a growing need to utilize alternative strategies when developing new antibacterial drugs. In this issue of Chemistry & Biology, Smith et al. explore the idea of antivirulence drugs by developing inhibitors of the type IV secretion system in Brucella.
随着常见细菌病原体对现有治疗手段的耐药性日益增强，在开发新型抗菌药物时，采用替代策略的需求也越来越大。在本期《化学生物学》中，史密斯等人通过开发布鲁氏菌IV型分泌系统的抑制剂，探讨了抗毒力药物的概念。
