含石榴皮提取物喷雾干燥微丸对白色念珠菌的活性。
Activity of spray-dried microparticles containing pomegranate peel extract against Candida albicans.
机构信息
Post Graduate Program in Pharmaceutical Sciences, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá 87020-900, Parana, Brazil.
出版信息
Molecules. 2012 Aug 24;17(9):10094-107. doi: 10.3390/molecules170910094.
Abstract
Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 µm and 2.80 µm, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models.
摘要
石榴因其化学成分和生物特性引起了研究人员的关注。它具有很强的抗氧化活性，对健康有益，同时还具有抗菌特性。本研究的目的是通过喷雾干燥技术生产含有石榴提取物的微球，利用海藻酸钠或壳聚糖作为包封剂。进行了表征和抗真菌试验。海藻酸钠微球的产率约为 40%，壳聚糖微球的产率约为 41%。平均粒径分别为 2.45 µm 和 2.80 µm，海藻酸钠和壳聚糖微球的包封效率分别为 81.9%和 74.7%。喷雾干燥过程保留了对白色念珠菌的抗真菌活性。这些结果可能有助于开发治疗念珠菌病的剂型，应在体内模型中进一步研究。
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