*Department of Ophthalmology †Cardiovascular Center, Semmelweis University, Budapest, Hungary.
J Glaucoma. 2014 Apr-May;23(4):195-8. doi: 10.1097/IJG.0b013e31826a9707.
To investigate the ability of different parameters of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) to detect early glaucomatous progression.
One eye of 17 healthy and 51 perimetric glaucoma patients was imaged prospectively at 6-month intervals for 1.5 to 3 years. Progression was determined by Octopus normal G2 visual field progression criteria.
Ten of the 51 glaucoma eyes progressed based on visual field criteria. Median visual field mean defect change was -0.300 dB/y for the controls, -0.120 dB/y for all glaucoma eyes (P=0.461 vs. controls), and 1.231 dB/y for the 10 functionally progressing glaucoma eyes (P<0.001 vs. controls). Ganglion cell complex (GCC), focal loss volume, and GCC global loss volume showed significantly faster rate of progression in the glaucoma group than in controls (P=0.004 and P=0.001, respectively). No optic nerve head, retinal nerve fiber layer thickness, and average GCC parameter separated the rate of progression between the groups.
Early structural progression of glaucoma may be better detected with pattern-based GCC parameters of the RTVue-OCT than with the optic nerve head, retinal nerve fiber layer thickness or average GCC parameters of the same instrument.
研究 RTVue-100 傅里叶域光学相干断层扫描仪（RTVue-OCT）的不同参数检测早期青光眼进展的能力。
前瞻性地对 17 名健康者和 51 名视野青光眼患者的一只眼进行 6 个月间隔的成像，时间为 1.5 至 3 年。通过 Octopus 正常 G2 视野进展标准确定进展。
根据视野标准，51 只青光眼眼中有 10 只进展。对照组的视野平均缺损变化中位数为-0.300 dB/y，所有青光眼眼为-0.120 dB/y（P=0.461 与对照组），10 只功能进展性青光眼眼为 1.231 dB/y（P<0.001 与对照组）。节细胞复合体（GCC）、局灶性损失体积和 GCC 全局损失体积在青光眼组中的进展速度明显快于对照组（P=0.004 和 P=0.001）。视神经头、视网膜神经纤维层厚度和平均 GCC 参数均不能区分两组的进展速度。
与同一仪器的视神经头、视网膜神经纤维层厚度或平均 GCC 参数相比，RTVue-OCT 的基于模式的 GCC 参数可能更好地检测青光眼的早期结构进展。
