Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Acta Paediatr. 2012 Dec;101(12):1211-6. doi: 10.1111/j.1651-2227.2012.02826.x. Epub 2012 Sep 10.
To characterize postnatal changes in serum insulin-like growth factor-1 (IGF-I) in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.
Longitudinal study of 108 infants with mean (SD) gestational age (GA) 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analysed from birth until postmenstrual age (PMA) 36 weeks. Multivariate models were developed to identify independent predictors of BPD.
Postnatal mean IGF-I levels at postnatal day (PND) 3-21 were lower in infants with BPD compared with infants with no BPD (16 vs. 26 μg/L, p < 0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (β)), PNDs 3-21, was lower in infants with BPD compared with infants with no BPD (0.28 vs. 0.97, p = 0.002) and mean IGF-I during PMA 30-33 weeks was lower in infants with BPD as compared with infants without BPD (22 vs. 29 μg/L, p < 0.001). In a binomial multiple regression model, lower GA, male gender and lower mean serum IGF-I levels during PND 3-21 were the most predictive risk factors associated with BPD (r(2) = 0.634, p < 0.001).
Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.
描述胰岛素样生长因子-1（IGF-1）在极早产儿血清中的变化与支气管肺发育不良（BPD）发生的关系。
对 108 例平均（标准差）胎龄（GA）为 27.2（2.2）周的极早产儿进行纵向研究。从出生到校正胎龄 36 周每周检测 IGF-I 血清样本。建立多变量模型以确定 BPD 的独立预测因素。
与无 BPD 的婴儿相比，BPD 婴儿出生后第 3-21 天的 IGF-I 水平较低（16 比 26μg/L，p<0.001）。与无 BPD 的婴儿相比，BPD 婴儿的 IGF-I 水平（IGF-I 回归系数（β））在出生后第 3-21 天呈下降趋势（0.28 比 0.97，p=0.002），在 PMA 30-33 周时的平均 IGF-I 水平也较低（22 比 29μg/L，p<0.001）。在二项式多元回归模型中，较低的 GA、男性和出生后第 3-21 天较低的平均 IGF-I 水平是与 BPD 相关的最具预测性的危险因素（r²=0.634，p<0.001）。
极早产儿出生后前几周 IGF-I 浓度较低与后期发生 BPD 有关。
