Laboratory of Pharmacology & Experimental Therapeutics, Institute for Biomedical Research on Light and Image, Coimbra University, 3000-548 Coimbra, Portugal.
Mediators Inflamm. 2011;2011:253061. doi: 10.1155/2011/253061. Epub 2011 Nov 15.
This study compares the effects of a single bout of exercise (acute extenuating) with those promoted by an exercise training program (chronic), focusing on low-grade chronic inflammation profile and on oxidative stress status, using the obese ZDF rats as a model of type 2 diabetes mellitus (T2DM). Animals were sacrificed after 12 weeks of a swimming training program and after a single bout of acute extenuating exercise. Glycaemic, insulinemic, and lipidic profile (triglycerides, total-cholesterol) were evaluated, as well as inflammatory (serum CRPhs, TNF-α, adiponectin) and oxidative (lipidic peroxidation and uric acid) status. When compared to obese diabetic sedentary rats, the animals submitted to acute exercise presented significantly lower values of glycaemia and insulinaemia, with inflammatory profile and oxidative stress significantly aggravated. The trained animals showed amelioration of glycaemic and lipidic dysmetabolism, accompanied by remarkable reduction of inflammatory and oxidative markers. In conclusion, the results presented herein suggessted that exercise pathogenesis-oriented interventions should not exacerbate underlying inflammatory stress associated with T2DM.
这项研究比较了单次运动（急性剧烈运动）和运动训练计划（慢性）的效果，研究聚焦于低水平慢性炎症特征和氧化应激状态，使用肥胖 ZDF 大鼠作为 2 型糖尿病（T2DM）模型。动物在 12 周游泳训练计划和单次急性剧烈运动后被处死。评估了血糖、胰岛素和血脂（甘油三酯、总胆固醇）水平，以及炎症（血清 CRPhs、TNF-α、脂联素）和氧化应激（脂质过氧化和尿酸）状态。与肥胖糖尿病静坐大鼠相比，进行急性运动的动物血糖和胰岛素水平显著降低，炎症特征和氧化应激显著加重。经过训练的动物表现出血糖和血脂代谢异常的改善，同时炎症和氧化应激标志物显著减少。总之，本文的结果表明，针对发病机制的运动干预不应加重与 T2DM 相关的潜在炎症应激。
