a Department of Pharmaceutical Chemistry , College of Pharmacy, S.R.M. University , Kattankulathur - 603 203 , Tamil Nadu , India.
Nat Prod Res. 2013;27(16):1463-7. doi: 10.1080/14786419.2012.717288. Epub 2012 Aug 29.
This study was carried out to evaluate the anti-nociceptive and anti-inflammatory activities of carbon tetrachloride extract (CTCE) of Azadirachta indica fruit skin and its isolated constituent azadiradione at two different dose levels (50 and 100 mg kg⁻¹ body weight). Anti-nociceptive screening by writhing test and hot-plate technique supported both peripheral and central mechanisms, respectively. Anti-inflammatory activity was observed using carrageenan-induced paw oedema model. The results concluded that the animals treated with 100 mg kg⁻¹ dose of CTCE and azadiradione exhibited significant anti-nociceptive and anti-inflammatory activities. This study had rationalised the ethnomedicinal use of the plant for wound, burns and injury by tribal people.
本研究旨在评估印楝果皮的四氯化碳提取物（CTCE）及其分离成分印楝酮在两个不同剂量水平（50 和 100mg/kg 体重）下的镇痛和抗炎活性。通过扭体试验和热板技术进行的镇痛筛选分别支持外周和中枢机制。使用角叉菜胶诱导的爪肿胀模型观察抗炎活性。结果表明，用 100mg/kg 剂量的 CTCE 和印楝酮处理的动物表现出显著的镇痛和抗炎活性。这项研究为部落人民将该植物用于伤口、烧伤和损伤的传统医学用途提供了合理化依据。
