Hassan Md Mynul, Uddin Shihab, Bhowmik Amrita, Ashraf Ayesha, Islam Md Mahmodul, Rokeya Begum
Department of Biotechnology and Genetic Engineering, Khulna University, Khulna, Bangladesh.
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Bangladesh.
Heliyon. 2022 Jan 13;8(1):e08771. doi: 10.1016/j.heliyon.2022.e08771. eCollection 2022 Jan.
is a gourd like blooming plant that is readily available in Bangladesh, requiring biological research to discover its therapeutic values. The goal of our research was to see if the ethanolic extract of this plant had any anti-hyperglycemic properties. Water, glibenclamide and extracts were fed to Streptozocin induced type-2 diabetic rat models at a dose of 1.25 g/kg body weight (bw) for 28 days to see what kind of effects they had on serum glucose, insulin, liver glycogen and lipid contents. Except for the control group, all the groups followed a pattern of maintaining the body weight. The oral glucose tolerance test was observed to be improved in extract after 14 days of the experiment. When assessed with the control group, the extract showed a significant ( = 0.0015) decrease in postprandial serum glucose level (M±SD, mmol/l, 13.23 ± 1.03 control Vs 11.47 ± 2.21 extract) at 120 min. The treatment of diabetic model rats with extract resulted in a 7% (p < 0.0001) reduction in serum cholesterol levels. While subsequent 28 days of treatment, insulin levels were found to be lowered in all groups (from 246.76 to 200.44 pg/dL; p < 0.0001 for standard and from 309.01 to 204.61 pg/dL; p < 0.0001 for sample). The results revealed that prolonged administration of improved the glycemic and lipidemic state of type-2 diabetic rats, implying that more research is needed to identify the active ingredient (s).
是一种类似葫芦的开花植物，在孟加拉国很常见，需要进行生物学研究来发现其治疗价值。我们研究的目的是观察这种植物的乙醇提取物是否具有抗高血糖特性。将水、格列本脲和提取物以1.25克/千克体重（bw）的剂量喂给链脲佐菌素诱导的2型糖尿病大鼠模型，持续28天，以观察它们对血清葡萄糖、胰岛素、肝糖原和脂质含量有何种影响。除对照组外，所有组均呈现出维持体重的模式。实验14天后观察到提取物组的口服葡萄糖耐量试验有所改善。与对照组相比，提取物组在120分钟时餐后血清葡萄糖水平显著降低（=0.0015）（平均值±标准差，毫摩尔/升，对照组13.23±1.03对比提取物组11.47±2.21）。用提取物治疗糖尿病模型大鼠可使血清胆固醇水平降低7%（p<0.0001）。在随后28天的治疗中，发现所有组的胰岛素水平均降低（标准组从246.76降至200.44皮克/分升；p<0.0001，样本组从309.01降至204.61皮克/分升；p<0.0001）。结果表明，长期给予提取物可改善2型糖尿病大鼠的血糖和血脂状态，这意味着需要更多研究来确定其活性成分。
