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钯催化的磺酸盐与 Boc 保护的氨甲基三氟硼酸钾之间的 Suzuki-Miyaura 交叉偶联反应。

Pd-catalyzed Suzuki-Miyaura cross-coupling reactions between sulfamates and potassium Boc-protected aminomethyltrifluoroborates.

机构信息

Roy and Diana A. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United States.

出版信息

Org Lett. 2013 May 17;15(10):2534-7. doi: 10.1021/ol401021x. Epub 2013 May 6.

DOI:10.1021/ol401021x
PMID:23646846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3796167/
Abstract

Sulfamates were studied as the electrophilic partners in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with potassium Boc-protected primary and secondary aminomethyltrifluoroborates. A broad range of substrates was successfully coupled to provide the desired products. Complex molecules containing a new carbon-carbon bond and an aminomethyl moiety could be prepared through this developed method.

摘要

磺酸盐被研究作为钯催化的 Suzuki-Miyaura 交叉偶联反应中的亲电试剂与 Boc 保护的伯胺和仲胺基甲基三氟硼酸钾反应。广泛的底物都能成功地进行偶联，得到所需的产物。通过这种开发的方法，可以制备含有新的碳-碳键和氨甲基部分的复杂分子。

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本文引用的文献

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Potassium Boc-protected secondary aminomethyltrifluoroborates: synthesis and Suzuki-Miyaura cross-coupling reactions.Boc 保护的仲氨甲基三氟硼酸盐的合成及 Suzuki-Miyaura 交叉偶联反应。
Org Lett. 2012 Sep 7;14(17):4458-61. doi: 10.1021/ol301955s. Epub 2012 Aug 29.
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Rapid and efficient access to secondary arylmethylamines.快速高效地获得仲芳基甲胺。
Chemistry. 2012 Jul 27;18(31):9564-70. doi: 10.1002/chem.201200831. Epub 2012 Jul 5.
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Iron-catalyzed alkylations of aryl sulfamates and carbamates.铁催化的芳基磺酸盐和氨基甲酸酯的烷基化反应。
Org Lett. 2012 Jul 20;14(14):3796-9. doi: 10.1021/ol301681z. Epub 2012 Jul 3.
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Suzuki-Miyaura cross-coupling reactions of potassium Boc-protected aminomethyltrifluoroborate with aryl and hetaryl mesylates.铃木-宫浦交叉偶联反应中，使用 Boc 保护的氨基甲基三氟硼酸钾与芳基和杂芳基甲磺酸酯反应。
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