Hamer Mark, Endrighi Romano, Poole Lydia
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK.
Methods Mol Biol. 2012;934:89-102. doi: 10.1007/978-1-62703-071-7_5.
Psychosocial factors, such as chronic mental stress and mood, are recognized as an important predictor of longevity and wellbeing. In particular, depression is independently associated with cardiovascular disease and all-cause mortality, and is often comorbid with chronic diseases that can worsen their associated health outcomes. Regular exercise is thought to be associated with stress reduction and better mood, which may partly mediate associations between depression, stress, and health outcomes. The underlying mechanisms for the positive effects of exercise on wellbeing remain poorly understood. In this overview we examine epidemiological evidence for an association between physical activity and mental health. We then describe the exercise withdrawal paradigm as an experimental protocol to study mechanisms linking exercise, mood, and stress. In particular we will discuss the potential role of the inflammatory response as a central mechanism.
社会心理因素，如长期精神压力和情绪，被认为是长寿和幸福的重要预测指标。特别是，抑郁症与心血管疾病和全因死亡率独立相关，并且常与可使相关健康结果恶化的慢性疾病共病。经常锻炼被认为与减轻压力和改善情绪有关，这可能部分介导了抑郁症、压力和健康结果之间的关联。运动对幸福感产生积极影响的潜在机制仍知之甚少。在本综述中，我们研究了身体活动与心理健康之间关联的流行病学证据。然后我们将运动戒断范式描述为一种研究运动、情绪和压力之间联系机制的实验方案。特别是，我们将讨论炎症反应作为核心机制的潜在作用。
