Department of Neurology, School of Medicine, University of Uludağ, 16059, Bursa, Turkey.
J Headache Pain. 2012 Oct;13(7):557-65. doi: 10.1007/s10194-012-0475-0. Epub 2012 Aug 31.
Sex hormones have some implications on headaches. The objective of the study was to investigate the effects of hormonal changes comparatively on tension-type headache (TTH) and migraine, in a population-based sample. A nationwide face-to-face prevalence study was conducted using a structured electronic questionnaire. 54.3 % of the migraineurs reported that the probability of experiencing headache during menstruation was high, whereas 3.9 % had headache only during menstruation. Forward logistic regression analysis revealed that menstruation was a significant trigger for migraine in comparison to TTH. On the other hand, nearly double the number of TTH sufferers reported "pure menstrual headache" compared to migraineurs (p = 0.02). Menstrual headaches caused significantly higher MIDAS grades. One-third of the definite migraineurs reported improvement during pregnancy and oral contraceptives significantly worsened migraine. Menopause had a slight improving effect on migraine compared to TTH. Sex hormonal changes have major impacts particularly on migraine; however, the effects of hormonal fluctuations on TTH should not be underestimated.
性激素对头痛有一定的影响。本研究旨在通过基于人群的样本，比较研究激素变化对紧张型头痛（TTH）和偏头痛的影响。采用结构化电子问卷进行了一项全国性的面对面患病率研究。偏头痛患者中有 54.3%报告说，在月经期间发生头痛的可能性很高，而 3.9%的人仅在月经期间发生头痛。向前逻辑回归分析表明，与 TTH 相比，月经是偏头痛的一个重要诱因。另一方面，与偏头痛患者相比，TTH 患者报告“单纯经期头痛”的人数几乎翻了一番（p=0.02）。经期头痛导致的 MIDAS 评分显著更高。三分之一的明确偏头痛患者报告在怀孕期间有所改善，口服避孕药会显著加重偏头痛。与 TTH 相比，更年期对偏头痛有轻微改善作用。性激素变化对偏头痛有重大影响；然而，激素波动对 TTH 的影响也不容忽视。
