Ostman J, Arner P, Engfeldt P, Kager L
Metabolism. 1979 Dec;28(12):1198-205. doi: 10.1016/0026-0495(79)90131-8.
Omental fat cells were 30% smaller than those in subcutaneous regions. In omental fat cells with a mean diameter of 95 mu, the basal cAMP concentration was 50% lower, but the basal rate of glycerol release was three times as rapid as in subcutaneous (epigastric) fat cells of identical size. Added at maximal effective concentration, noradrenaline increased the level of cAMP and the rate of glycerol release more markedly in the omental than in the subcutaneous adipocytes, whereas the response to isopropyl noradrenaline was similar. Before starvation the lipolytic effects of noradrenaline and isopropyl noradrenaline, respectively, were identical in the two regions of subcutaneous adipose tissue investigated (femoral and hypogastric). The findings were well related to the tissue levels of cAMP induced by the two agents. During starvation noradrenaline and isopropyl noradrenaline increased the cAMP level and the rate of lipolysis in fat cells obtained from the hypogastric region, whereas noradrenaline decreased these parameters in femoral adipocytes. Starvation was associated with a more prominent inhibitory effect of phenylephrine on basal and isopropyl-noradrenaline-induced lipolysis in femoral than in hypogastric adipose tissue. In conclusion, differences exist between different regions of adipose tissue in their lipolytic responsiveness to noradrenaline, which seems related to the balance between alpha- and beta-adrenergic receptor response.
网膜脂肪细胞比皮下区域的脂肪细胞小30%。在平均直径为95微米的网膜脂肪细胞中，基础环磷酸腺苷（cAMP）浓度低50%，但基础甘油释放速率比相同大小的皮下（上腹部）脂肪细胞快三倍。以最大有效浓度添加时，去甲肾上腺素使网膜脂肪细胞中的cAMP水平和甘油释放速率的增加比皮下脂肪细胞更明显，而异丙基去甲肾上腺素的反应相似。在饥饿前，在所研究的皮下脂肪组织的两个区域（股部和下腹部）中，去甲肾上腺素和异丙基去甲肾上腺素的脂解作用分别相同。这些发现与两种药物诱导的组织cAMP水平密切相关。在饥饿期间，去甲肾上腺素和异丙基去甲肾上腺素增加了从下腹部区域获得的脂肪细胞中的cAMP水平和脂解速率，而去甲肾上腺素降低了股部脂肪细胞中的这些参数。饥饿与去氧肾上腺素对股部脂肪组织基础脂解和异丙基去甲肾上腺素诱导的脂解的抑制作用比下腹部脂肪组织更显著有关。总之，脂肪组织的不同区域对去甲肾上腺素的脂解反应性存在差异，这似乎与α-和β-肾上腺素能受体反应之间的平衡有关。
