壳聚糖网络的合成：使用 Fe3O4 纳米粒子的溶胀、药物释放和磁辅助 BSA 分离。
Synthesis of chitosan networks: Swelling, drug release, and magnetically assisted BSA separation using Fe3O4 nanoparticles.
机构信息
Polymer Research Laboratory, Department of Chemistry, University of Mazandaran, Babolsar, 47416-95447, Iran.
出版信息
Carbohydr Polym. 2012 Oct 15;90(3):1265-72. doi: 10.1016/j.carbpol.2012.06.069. Epub 2012 Jul 2.
Chitosan (CS) nanohydrogel networks were prepared by reaction with glyceroldiglycidylether (GDE) and poly(dimethylsiloxane) (PDMS), as crosslinking agents in an emulsion system. The nanogel content increased with increasing the amount of crosslinkers and reached to a maximum of 90% with GDE. The nanogels structure was characterized by FT-IR, AFM, DSC, and TGA. The average size for CS-GDE and CS-PDMS particles were 59nm and 180nm, respectively. The swelling behavior of nanohydrogels was observed to be dependent on pH, temperature, degree of crosslinking, and on the chemical structure of crosslinker. The equilibrium water content of CS-GDE nanohydrogels reached to a maximum of 600% at neutral pH, and decreased at high and low pH and low temperature. These nanohydrogels were tested for sodium diclofenac (SDF) loading and releasing efficiency. The covalent conjugation of bovine serum albumin (BSA) and magnetic Fe(3)O(4) nanoparticles on the hydrogels were found to hold a potential application in magnetically assisted bioseparation.
壳聚糖（CS）纳米水凝胶网络通过与甘油二缩水甘油醚（GDE）和聚二甲基硅氧烷（PDMS）反应制备，作为乳液体系中的交联剂。纳米凝胶含量随着交联剂用量的增加而增加，用 GDE 时达到最大值 90%。纳米凝胶的结构通过傅里叶变换红外光谱（FT-IR）、原子力显微镜（AFM）、差示扫描量热法（DSC）和热重分析（TGA）进行了表征。CS-GDE 和 CS-PDMS 颗粒的平均粒径分别为 59nm 和 180nm。纳米水凝胶的溶胀行为取决于 pH 值、温度、交联度以及交联剂的化学结构。CS-GDE 纳米水凝胶在中性 pH 值时达到最大平衡水含量 600%，在高 pH 值、低 pH 值和低温时降低。这些纳米水凝胶被测试用于负载和释放双氯芬酸钠（SDF）的效率。牛血清白蛋白（BSA）和磁性 Fe(3)O(4)纳米粒子的共价接枝到水凝胶上，有望在磁性辅助生物分离中得到应用。
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