通过多焦视网膜电图评估青光眼患者黄斑功能
Assessment of macular function of glaucomatous eyes by multifocal electroretinograms.
作者信息
Hori Nobuhide, Komori Shinya, Yamada Hiroki, Sawada Akira, Nomura Yasunori, Mochizuki Kiyofumi, Yamamoto Tetsuya
机构信息
Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.
出版信息
Doc Ophthalmol. 2012 Dec;125(3):235-47. doi: 10.1007/s10633-012-9351-0. Epub 2012 Sep 4.
PURPOSE
To determine whether significant correlations existed between the morphological and functional parameters of the macular region of eyes with open-angle glaucoma (OAG).
METHODS
Forty eyes of 40 OAG patients were studied. The morphological parameters were obtained by optical coherence tomography (OCT), and the functional parameters were acquired by automated Humphrey Field Analyzer (HFA) and multifocal electroretinograms (mfERGs). All of the tests were performed within 6 months of each other. The retinal thickness was determined by OCT in the nine Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors of the macula, the fovea, and the four quadrants of the inner and an outer ring. The amplitudes of the second-order kernel responses of the mfERGs in the central 5° including the amplitude ratio of the nasal to temporal hemispheres (N/T amplitude ratio) were analyzed. The total mean deviation of the HFA corresponding to each OCT region was measured. The correlation between the different parameters was determined by coefficients of correlation and linear regression analyses.
RESULTS
The N/T amplitude ratio of the second-order kernel responses of the mfERGs was significantly correlated with the retinal thickness in the inferior quadrant (r = -0.44; P = 0.004). There was a significant correlation between the N/T amplitude ratio and the threshold in the superior quadrant measured by the HFA Central 10-2 program (r = -0.40; P = 0.011) and also between the N/T amplitude ratio and the total deviation in the superior quadrant (r = -0.40; P = 0.010). There were significant correlations between the inferior retinal thickness and the average threshold and the TD in superior (r = 0.70, P < 0.001; r = 0.692, P < 0.001, respectively), nasal (r = 0.53, P < 0.001; r = 0.53, P < 0.001, respectively), and temporal (r = 0.46, P = 0.003; r = 0.44, P = 0.004, respectively) quadrants.
CONCLUSIONS
Functional glaucomatous changes determined by mfERGs and perimetry are significantly correlated with the morphological changes determined by OCT.
目的
确定开角型青光眼（OAG）患者眼部黄斑区的形态学参数与功能参数之间是否存在显著相关性。
方法
对40例OAG患者的40只眼睛进行研究。通过光学相干断层扫描（OCT）获取形态学参数，通过自动 Humphrey 视野分析仪（HFA）和多焦视网膜电图（mfERG）获取功能参数。所有测试均在彼此6个月内完成。通过OCT在黄斑的九个糖尿病视网膜病变早期治疗研究（ETDRS）区域、中央凹以及内环和外环的四个象限中测定视网膜厚度。分析mfERG在中央5°区域的二阶核反应的振幅，包括鼻侧与颞侧半球的振幅比（N/T振幅比）。测量与每个OCT区域相对应的HFA的总平均偏差。通过相关系数和线性回归分析确定不同参数之间的相关性。
结果
mfERG的二阶核反应的N/T振幅比与下象限的视网膜厚度显著相关（r = -0.44；P = 0.004）。N/T振幅比与HFA中央10-2程序测量的上象限阈值之间存在显著相关性（r = -0.40；P = 0.011），并且N/T振幅比与上象限的总偏差之间也存在显著相关性（r = -0.40；P = 0.010）。下视网膜厚度与上象限（分别为r = 0.70，P < 0.001；r = 0.692，P < 0.001）、鼻侧（分别为r = 0.53，P < 0.001；r = 0.53，P < 0.001）和颞侧（分别为r = 0.46，P = 0.003；r = 0.44，P = 0.004）象限的平均阈值和总偏差之间存在显著相关性。
结论
mfERG和视野检查所确定的青光眼性功能性改变与OCT所确定的形态学改变显著相关。
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