Center for Regenerative Therapies Dresden and the German Center for Neurodegenerative Diseases, Fetscherstraße 105, 01307 Dresden, Germany.
Nat Rev Neurosci. 2012 Oct;13(10):727-36. doi: 10.1038/nrn3319. Epub 2012 Sep 5.
Adult neurogenesis is often considered an archaic trait that has undergone a 'phylogenetic reduction' from amphibian ancestors to humans. However, adult neurogenesis in the hippocampal dentate gyrus might actually be a late-evolved trait. In non-mammals, adult hippocampal neurogenesis is not restricted to the equivalents of the dentate gyrus, which also show different connectivity and functionality compared to their mammalian counterpart. Moving actively in a changing world and dealing with novelty and complexity regulate adult neurogenesis. New neurons might thus provide the cognitive adaptability to conquer ecological niches rich with challenging stimuli.
成人神经发生通常被认为是一种古老的特征，它经历了从两栖动物祖先到人类的“系统发生缩减”。然而，海马齿状回中的成人神经发生实际上可能是一种后进化的特征。在非哺乳动物中，成年海马神经发生不仅限于齿状回的等效物，与哺乳动物相比，它们的连接和功能也不同。在不断变化的世界中积极移动，应对新奇和复杂性，调节着成人神经发生。新神经元因此可能为认知适应性提供了征服富含挑战性刺激的生态位的能力。
