Bae Jae Jun, Choi Seock Hwan, Kwon Tae Gyun, Kim Tae-Hwan
Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea.
Korean J Urol. 2012 Aug;53(8):536-40. doi: 10.4111/kju.2012.53.8.536. Epub 2012 Aug 16.
Obesity has been suggested as a risk factor for worse perioperative outcomes, especially in radical prostatectomy, in several studies. However, the impact of obesity on perioperative outcomes has not yet been well elucidated for robot-assisted laparoscopic radical prostatectomy (RALP). We evaluated whether obesity had an adverse effect on outcomes following RALP compared with retropubic radical prostatectomy (RRP).
From April 2008 to May 2011, 181 patients underwent radical prostatectomy (RALP, 111; RRP, 70). These patients were subdivided into two groups according to body mass index (BMI): the nonobese group (BMI, 25 kg/m(2) or less) and the obese group (BMI, greater than 25 kg/m(2)). Perioperative outcomes in RALP and RRP were retrospectively compared between the two groups.
In RRP, patients in the obese group (n=20) showed greater blood loss and a higher complication rate than did those in the nonobese group (n=50). However, in RALP, no statistically significant differences in perioperative outcomes were observed between the obese (n=37) and the nonobese (n=74) groups. RALP showed less blood loss and a lower complication rate in both the obese and nonobese groups than did RRP.
RALP is thought to be a more effective and safer procedure in obese patients compared with traditional open radical prostatectomy. In the management of obese patients with localized prostate cancer, RALP should be considered as a primary choice for treatment.
多项研究表明,肥胖被认为是围手术期预后较差的一个风险因素,尤其是在根治性前列腺切除术中。然而,肥胖对机器人辅助腹腔镜根治性前列腺切除术(RALP)围手术期预后的影响尚未得到充分阐明。我们评估了与耻骨后根治性前列腺切除术(RRP)相比,肥胖对RALP术后预后是否有不利影响。
2008年4月至2011年5月,181例患者接受了根治性前列腺切除术(RALP,111例;RRP,70例)。这些患者根据体重指数(BMI)分为两组:非肥胖组(BMI为25kg/m²或更低)和肥胖组(BMI大于25kg/m²)。回顾性比较两组RALP和RRP的围手术期预后。
在RRP中,肥胖组(n = 20)患者的失血量比非肥胖组(n = 50)更多,并发症发生率更高。然而,在RALP中,肥胖组(n = 37)和非肥胖组(n = 74)之间在围手术期预后方面未观察到统计学上的显著差异。与RRP相比,RALP在肥胖组和非肥胖组中的失血量均较少,并发症发生率较低。
与传统开放性根治性前列腺切除术相比,RALP被认为对肥胖患者是一种更有效、更安全的手术方法。在肥胖局限性前列腺癌患者的治疗中,RALP应被视为主要的治疗选择。