Höh H, Schirra F, Kienecker C, Ruprecht K W
Augenklinik, Klinikum Neubrandenburg, Akademisches Lehrkrankenhaus. Ernst-Moritz-Arndt-Universität, Greifswald.
Ophthalmologe. 1995 Dec;92(6):802-8.
Dry eye syndromes are becoming more important for the ophthalmologist. Various circumstances lead to a significant impairment of the three layered precorneal film, whose disturbed equilibrium causes diverse pathological changes in the ocular surface. Apart from symptoms and clinical signs, various clinical tests and laboratory procedures can be used to confirm the diagnosis. We looked at the utility of the lid-parallel conjunctival fold (LIPCOF) with regard to the diagnosis "dry eye". In this publication we describe and classify LIPCOF, stage 0 to stage 3, and investigate its relationship to the severity of dry eye. Dryness is determined by the "sicca score", a scale between 0 and 12 based on a wide-ranging spectrum of tests, including the Schirmer I-test, tear-film break-up time, rose bengal and and fluorescein staining, the lysozyme test and impression cytology. In this prospective study we examined one eye in each of 267 patients, assigning them to one of two groups based on the absence or presence of LIPCOF. These two groups are comparable in gender and age (group-matching). For the diagnosis of dry eye, using LIPCOF, statistical analysis of the data showed a negative predictive value of 75.95% and a positive predictive value of 93.09%. The correlation pattern of LIPCOF with the patient's medical history and slit-lamp. They are a dependable diagnostic sigh of dry eye. Consideration and classification of LIPCOF enlarges and facilitates diagnosis of dry eye syndromes by the ophthalmologist.
干眼综合征对眼科医生来说正变得越来越重要。多种情况会导致角膜前三层膜严重受损，其平衡失调会引起眼表各种病理变化。除了症状和临床体征外，还可通过各种临床检查和实验室操作来确诊。我们研究了睑平行结膜皱襞（LIPCOF）在“干眼”诊断中的效用。在本出版物中，我们描述并将LIPCOF分为0期至3期，并研究其与干眼严重程度的关系。干燥程度由“干眼评分”确定，该评分基于包括Schirmer I试验、泪膜破裂时间、孟加拉玫瑰红和荧光素染色、溶菌酶试验及印迹细胞学等广泛的检测项目，范围在0至12分之间。在这项前瞻性研究中，我们检查了267例患者的单眼，根据是否存在LIPCOF将他们分为两组。这两组在性别和年龄上具有可比性（组间匹配）。对于使用LIPCOF诊断干眼，数据的统计分析显示其阴性预测值为75.95%，阳性预测值为93.09%。LIPCOF与患者病史及裂隙灯检查的相关模式。它们是干眼的可靠诊断体征。对LIPCOF的考量和分类扩大并便于眼科医生对干眼综合征的诊断。
