Haiden Mio, Miyasaka Yoko, Kimura Yutaka, Tsujimoto Satoshi, Maeba Hirofumi, Suwa Yoshinobu, Iwasaka Toshiji, Shiojima Ichiro
Mio Haiden, Yoko Miyasaka, Yutaka Kimura, Satoshi Tsujimoto, Hirofumi Maeba, Yoshinobu Suwa, Toshiji Iwasaka, Ichiro Shiojima, Division of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka 573-1191, Japan.
World J Cardiol. 2012 Aug 26;4(8):256-9. doi: 10.4330/wjc.v4.i8.256.
To evaluate the effects of eicosapentaenoic acid (EPA) on regional arterial stiffness assessed by strain rate using tissue Doppler imaging.
Nineteen eligible patients were prospectively studied (mean age 62 ± 8 years, 68% men). Subjects with large vessel complications and/or diabetes mellitus were excluded. The strain rate of the ascending aorta was measured by tissue Doppler imaging as an index of regional arterial stiffness, and brachial-ankle pulse wave velocity (baPWV) was measured as an index of degree of systemic arteriosclerosis. These indices were compared before and after administration of EPA at 1800 mg/d for one year.
The plasma concentration of EPA increased significantly after EPA administration (3.0% ± 1.1% to 8.5% ± 2.9%, P < 0.001). There were no significant changes in baPWV (1765 ± 335 cm/s to 1745 ± 374 cm/s), low-density lipoprotein cholesterol levels (114 ± 29 mg/dL to 108 ± 28 mg/dL), or systolic blood pressure (131 ± 16 mmHg to 130 ± 13 mmHg) before and after EPA administration. In contrast, the strain rate was significantly increased by administration of EPA (19.2 ± 5.6 s(-1), 23.0 ± 6.6 s(-1), P < 0.05).
One year of administration of EPA resulted in an improvement in regional arterial stiffness which was independent of blood pressure or serum cholesterol levels.
通过组织多普勒成像使用应变率评估二十碳五烯酸（EPA）对局部动脉僵硬度的影响。
对19例符合条件的患者进行前瞻性研究（平均年龄62±8岁，68%为男性）。排除有大血管并发症和/或糖尿病的受试者。通过组织多普勒成像测量升主动脉的应变率作为局部动脉僵硬度的指标，并测量臂踝脉搏波速度（baPWV）作为全身动脉硬化程度的指标。在给予1800mg/d的EPA一年前后比较这些指标。
给予EPA后血浆EPA浓度显著升高（3.0%±1.1%至8.5%±2.9%，P<0.001）。给予EPA前后baPWV（1765±335cm/s至1745±374cm/s）、低密度脂蛋白胆固醇水平（114±29mg/dL至108±28mg/dL）或收缩压（131±16mmHg至130±13mmHg）均无显著变化。相比之下，给予EPA后应变率显著增加（19.2±5.6s⁻¹，23.0±6.6s⁻¹，P<0.05）。
给予EPA一年可改善局部动脉僵硬度，且这种改善与血压或血清胆固醇水平无关。
