Research Laboratories for Fundamental Technology of Food, Asahi Breweries Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 305-0106, Japan.
Food Research Institute, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba-shi, Ibaraki 305-8605, Japan.
Nutrients. 2020 Apr 13;12(4):1071. doi: 10.3390/nu12041071.
This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20-39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women.
本临床研究旨在评估连续给予苹果多酚（AP）对健康女性参与者因紫外线（UV）照射引起的面部皮肤状况和色素沉着的影响。将 65 名参与者（年龄 20-39 岁）随机分为两组，分别给予含有 AP（300 或 600mg/天）或安慰剂的片剂，进行双盲、安慰剂对照临床试验。连续 12 周给予 AP 可显著预防 UV 照射引起的皮肤色素沉着（红斑值、黑色素值、L 值），尽管未观察到剂量依赖性关系。然而，两组之间的皮肤水分含量和经表皮水分损失没有显著差异。我们的研究表明，AP 及其主要活性化合物原花青素具有多种健康益处。在这里，我们报告称，与安慰剂相比，连续 12 周给予 AP 可缓解健康女性因 UV 照射引起的皮肤色素沉着。
