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用发射光谱法检测犬的静脉空气栓塞。

Detection of venous air embolism in dogs by emission spectrometry.

作者信息

Russell G B, Richard R B, Snider M T

机构信息

Department of Anesthesia, Pennsylvania State University, College of Medicine, University Hospital, Milton S. Hershey Medical Center, Hershey 17033.

出版信息

J Clin Monit. 1990 Jan;6(1):18-23. doi: 10.1007/BF02832178.

Abstract

Emission spectrometers provide alternative, relatively inexpensive methods for detecting the concentration of respiratory gas nitrogen. Mass spectrometers are accepted as reliable monitors of end-tidal nitrogen for detection of venous air embolisms. We evaluated an inexpensive emission spectrometer for detecting changes in nitrogen levels and compared it with a mass spectrometer for detecting increased end-tidal nitrogen levels in dogs with venous air embolisms. During in vitro gas flow studies (helium; oxygen; helium/oxygen mixtures; or 70% nitrous oxide/30% oxygen with 0, 1, 2, or 3% isoflurane), air boluses (0.01 to 5.0 ml) were injected into a gas flow circuit and outlet nitrogen levels were measured by a Collins 21232 emission spectrometer. Responses were greater after each bolus when helium rather than oxygen was the major diluent gas. During in vivo studies, 5 dogs were anesthetized, ventilated, denitrogenated, and given venous air embolisms (0.1, 0.5, and 1.0 ml.kg-1) during oxygen and then during Heliox (20% oxygen:80% helium) breathing. End-tidal nitrogen increased approximately two-fold after venous air embolisms given during Heliox as compared with oxygen ventilation. In all 0.1-ml.kg-1 venous air embolisms end-tidal nitrogen increased when the emission spectrometer was used, but venous air embolisms less than 1.0 ml.kg-1 were not consistently detected by mass spectrometry. Emission spectrometry can be used to detect increased end-tidal nitrogen levels indicative of venous air embolism and may be a more sensitive detector than mass spectrometry.

摘要

发射光谱仪提供了检测呼吸气体中氮气浓度的替代方法,且相对便宜。质谱仪被公认为是检测呼气末氮气以发现静脉空气栓塞的可靠监测设备。我们评估了一种用于检测氮气水平变化的廉价发射光谱仪,并将其与质谱仪进行比较,以检测患有静脉空气栓塞的犬类呼气末氮气水平的升高。在体外气流研究中(氦气;氧气;氦气/氧气混合物;或含0、1、2或3%异氟烷的70%氧化亚氮/30%氧气),将空气团(0.01至5.0毫升)注入气流回路,并通过柯林斯21232发射光谱仪测量出口氮气水平。当氦气而非氧气作为主要稀释气体时,每次注入空气团后的反应更大。在体内研究中,对5只犬进行麻醉、通气、去氮,并在吸氧期间以及随后吸入氦氧混合气(20%氧气:80%氦气)期间给予静脉空气栓塞(0.1、0.5和1.0毫升·千克⁻¹)。与氧气通气相比,在吸入氦氧混合气期间给予静脉空气栓塞后,呼气末氮气增加了约两倍。在所有0.1毫升·千克⁻¹的静脉空气栓塞中,使用发射光谱仪时呼气末氮气增加,但质谱法未能始终检测到小于1.0毫升·千克⁻¹的静脉空气栓塞。发射光谱法可用于检测指示静脉空气栓塞的呼气末氮气水平升高,并且可能是比质谱法更灵敏的检测方法。

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