Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Medical Research Laboratories, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
J Appl Physiol (1985). 2012 Nov;113(9):1432-8. doi: 10.1152/japplphysiol.00816.2012. Epub 2012 Sep 6.
Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.
老年人的肌腱胶原含量和循环生长激素（GH）减少。在一项安慰剂对照、双盲研究中，我们研究了局部注射 rhGH 是否能增强健康老年男性（61±1 岁）的胶原合成。分别向每位患者的髌腱内注射 2 次 rhGH 或生理盐水（对照）。随后，测量肌腱胶原分数合成率（FSR）和 I 型胶原合成的间接标志物（PINP）。在最后一次注射后的头 6 小时内，12 名受试者中有 10 名（P=0.08）出现肌腱胶原 FSR 升高的趋势。同样，在最后一次 GH 注射后 3-4 小时，PINP 升高（P=0.05）。血清 IGF-I 从基线没有变化，而 GH 组的腱周生物活性 IGF-I 高于对照组（P=0.05）。总之，rhGH 局部注射可增加人体肌腱胶原合成，其作用途径可能是直接或通过增加局部生物活性 IGF-I。
