Department of Physical Therapy, School of Nursing and Health Professions, Georgia State University, Atlanta, Georgia 30303, USA.
J Hand Ther. 2013 Apr-Jun;26(2):162-70; quiz 171. doi: 10.1016/j.jht.2012.07.002. Epub 2012 Sep 8.
Systematic review and meta-analysis.
Prior reviews on the effects of anodal transcranial direct current stimulation (a-tDCS) have shown the effectiveness of a-tDCS on corticomotor excitability and motor function in healthy individuals but nonsignificant effect in subjects with stroke.
To summarize and evaluate the evidence for the efficacy of a-tDCS in the treatment of upper limb motor impairment after stroke.
A meta-analysis of randomized controlled trials that compared a-tDCS with placebo and change from baseline.
A pooled analysis showed a significant increase in scores in favor of a-tDCS (standard mean difference [SMD]=0.40, 95% confidence interval [CI]=0.10-0.70, p=0.010, compared with baseline). A similar effect was observed between a-tDCS and sham (SMD=0.49, 95% CI=0.18-0.81, p=0.005).
This meta-analysis of eight randomized placebo-controlled trials provides further evidence that a-tDCS may benefit motor function of the paretic upper limb in patients suffering from chronic stroke.
Level 1a.
系统评价和荟萃分析。
先前关于阳极经颅直流电刺激（a-tDCS）效果的综述表明，a-tDCS 对健康个体的皮质运动兴奋性和运动功能有效，但对中风患者则无效。
总结和评估 a-tDCS 治疗中风后上肢运动障碍的疗效证据。
对随机对照试验进行荟萃分析，比较 a-tDCS 与安慰剂和从基线的变化。
汇总分析显示，a-tDCS 组的评分明显增加（优势比[SMD]=0.40，95%置信区间[CI]=0.10-0.70，p=0.010，与基线相比）。a-tDCS 与假刺激组之间也观察到类似的效果（SMD=0.49，95% CI=0.18-0.81，p=0.005）。
这项对八项随机安慰剂对照试验的荟萃分析进一步提供了证据，表明 a-tDCS 可能有益于慢性中风患者患侧上肢的运动功能。
1a 级。
