Wu Tao, Xu Yun-hua, Ye Xiao-lei
Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qing-Chun Road, Hangzhou, 310003, People's Republic of China,
Tumour Biol. 2013 Oct;34(5):2611-5. doi: 10.1007/s13277-013-0810-3. Epub 2013 May 8.
There were many studies performed to assess the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population, but contradictory results were reported. To provide a comprehensive and objective assessment of the association, a meta-analysis of all eligible case-control studies was carried out. After searching the databases and reading the abstracts, 12 case-control studies on the association between XRCC1 Arg194Trp polymorphism and lung cancer risk were finally included into this meta-analysis. Those 12 studies included a total of 4,385 cases and 4,545 controls. XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model, odds ratio (OR) = 1.12, 95 % confidence interval (CI) 1.00-1.26, P = 0.049; homozygote model, OR = 1.27, 95 % CI 1.09-1.48, P = 0.003; recessive model, OR = 1.26, 95 % CI 1.09-1.46, P = 0.003). However, there was no obvious association between XRCC1 Arg194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98-1.16, P = 0.146). Sensitivity analysis suggested the stability and liability of this meta-analysis. Therefore, this meta-analysis suggests that XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population.
已有许多研究评估X射线修复交叉互补基因1（XRCC1）的Arg194Trp多态性与中国汉族人群肺癌风险之间的关联，但报道的结果相互矛盾。为了对这种关联进行全面、客观的评估，我们对所有符合条件的病例对照研究进行了荟萃分析。在检索数据库并阅读摘要后，最终有12项关于XRCC1 Arg194Trp多态性与肺癌风险关联的病例对照研究被纳入该荟萃分析。这12项研究共纳入4385例病例和4545例对照。在三种主要模型下，XRCC1 Arg194Trp多态性与中国汉族人群肺癌风险增加相关（等位基因对比模型，比值比（OR）=1.12，95%置信区间（CI）1.00 - 1.26，P = 0.049；纯合子模型，OR = 1.27，95% CI 1.09 - 1.48，P = 0.003；隐性模型，OR = 1.26，95% CI 1.09 - 1.46，P = 0.003）。然而，在显性模型下，XRCC1 Arg194Trp多态性与肺癌风险之间没有明显关联（OR = 1.06，95% CI 0.98 - 1.16，P = 0.146）。敏感性分析表明该荟萃分析具有稳定性和可靠性。因此，该荟萃分析表明XRCC1 Arg194Trp多态性与中国汉族人群肺癌风险增加相关。
