评估超声辅助溶栓治疗视网膜静脉阻塞模型中定制脂质体的效果。
Evaluation of ultrasound-assisted thrombolysis using custom liposomes in a model of retinal vein occlusion.
机构信息
Doheny Eye Institute, Los Angeles, CA 90033, USA.
出版信息
Invest Ophthalmol Vis Sci. 2012 Oct 5;53(11):6920-7. doi: 10.1167/iovs.12-10389.
PURPOSE
To study the potential efficacy of ultrasound (US) assisted by custom liposome (CLP) destruction as an innovative thrombolytic tool for the treatment of retinal vein occlusion (RVO).
METHODS
Experimental RVO was induced in the right eyes of 40 rabbits using laser photothrombosis; the US experiment took place 48 hours later. Rabbits were randomly divided into four equal groups: US+CLP group, US+saline group, CLP+sham US group, and no treatment group. The latter three groups acted as controls. Fundus fluorescein angiography and Doppler US were used to evaluate retinal blood flow.
RESULTS
CLP-assisted US thrombolysis resulted in restoration of flow in seven rabbits (70%). None of the control groups showed significant restoration of retinal venous blood flow.
CONCLUSIONS
US-assisted thrombolysis using liposomes resulted in a statistically significant reperfusion of retinal vessels in the rabbit experimental model of RVO. This approach might be promising in the treatment of RVO in humans. Further studies are needed to evaluate this approach in patients with RVO. Ultrasound assisted thrombolysis can be an innovative tool in management of retinal vein occlusion.
目的
研究超声（US）辅助定制脂质体（CLP）破坏作为治疗视网膜静脉阻塞（RVO）的新型溶栓工具的潜在疗效。
方法
使用激光光血栓形成在 40 只兔子的右眼诱导实验性 RVO；US 实验在 48 小时后进行。兔子被随机分为四组：US+CLP 组、US+盐水组、CLP+假 US 组和无治疗组。后三组作为对照组。眼底荧光血管造影和多普勒 US 用于评估视网膜血流。
结果
CLP 辅助 US 溶栓导致 7 只兔子（70%）的血流恢复。对照组均未观察到视网膜静脉血流明显恢复。
结论
超声辅助脂质体溶栓在兔 RVO 实验模型中导致视网膜血管的再灌注具有统计学意义。这种方法在治疗人类 RVO 中可能具有广阔的前景。需要进一步的研究来评估这种方法在 RVO 患者中的应用。超声辅助溶栓可能是治疗视网膜静脉阻塞的一种创新工具。
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