Wang Weidong, Lang Jinyi
Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu 610041, P.R. China.
Exp Ther Med. 2012 Aug;4(2):175-180. doi: 10.3892/etm.2012.593. Epub 2012 May 30.
Rapid developments in radiation oncology are currently taking place. Radiation-induced responses are being increasingly used for radiotherapy modification based on advancements in radiobiology. In the process of radiation treatment, radiobiological responses of tumor and normal tissue in patients are monitored non-invasively by a variety of techniques including imaging, biological methods and biochemical assays. Information collected using these methods and data on responses are further incorporated into radiotherapy optimization approaches, which not only include the optimization of radiation treatment planning, such as dose distributions in targets and treatment delivery, but also include radiation sensitivity modification and gene radiotherapy of the tumor and normal tissue. Hence, the highest tumor control rate is obtained with the utmost protection being afforded to normal tissue under this treatment modality.
放射肿瘤学目前正在迅速发展。基于放射生物学的进展，辐射诱导反应越来越多地用于放疗调整。在放射治疗过程中，通过包括成像、生物学方法和生化分析在内的多种技术对患者肿瘤和正常组织的放射生物学反应进行无创监测。使用这些方法收集的信息以及反应数据进一步纳入放疗优化方法中，这不仅包括放射治疗计划的优化，如靶区剂量分布和治疗实施，还包括肿瘤和正常组织的放射敏感性改变及基因放疗。因此，在这种治疗模式下，在最大程度保护正常组织的同时可获得最高的肿瘤控制率。
