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原发性巨细胞病毒肺炎经皮质类固醇治疗和缬更昔洛韦治疗后成功治愈。

Primary Cytomegalovirus Pneumonia Successfully Treated with Corticosteroid Therapy and Valganciclovir.

机构信息

Department of Respiratory Medicine, Saiseikai Yokohamashi Tobu Hospital, Japan.

Department of Diagnostic Pathology, Saiseikai Yokohamashi Tobu Hospital, Japan.

出版信息

Intern Med. 2024 Jan 15;63(2):271-276. doi: 10.2169/internalmedicine.1638-23. Epub 2023 May 24.

DOI:10.2169/internalmedicine.1638-23
PMID:37225488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10864076/
Abstract

Cytomegalovirus infection is typically asymptomatic in immunocompetent individuals. A 26-year-old woman was admitted to our hospital with a fever and breathlessness. Chest computed tomography (CT) revealed bilateral diffuse reticulation and nodules. Laboratory investigations showed atypical lymphocytosis and increased transaminases. She was treated with corticosteroid pulse therapy because of acute lung injury, and her clinical condition improved. Based on the presence of cytomegalovirus antibodies, antigen, and polymerase chain reaction findings, she was diagnosed with primary cytomegalovirus pneumonia and treated with valganciclovir. Primary cytomegalovirus pneumonia is very rare in immunocompetent individuals. The efficacy of corticosteroid and valganciclovir against cytomegalovirus pneumonia in this patient is noteworthy.

摘要

巨细胞病毒感染在免疫功能正常的个体中通常无症状。一名 26 岁女性因发热和呼吸困难入院。胸部计算机断层扫描（CT）显示双侧弥漫性网状和结节。实验室检查显示非典型淋巴细胞增多和转氨酶升高。由于急性肺损伤，她接受了糖皮质激素脉冲治疗，临床状况有所改善。根据巨细胞病毒抗体、抗原和聚合酶链反应结果，她被诊断为原发性巨细胞病毒肺炎，并接受缬更昔洛韦治疗。免疫功能正常的个体中，原发性巨细胞病毒肺炎非常罕见。在该患者中，糖皮质激素和缬更昔洛韦治疗巨细胞病毒肺炎的疗效值得注意。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/ad4609abe8a4/1349-7235-63-0271-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/e5aa33b007b7/1349-7235-63-0271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/87ccacfc31be/1349-7235-63-0271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/bd52b9abc7f2/1349-7235-63-0271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/b8824d20399e/1349-7235-63-0271-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/ad4609abe8a4/1349-7235-63-0271-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/e5aa33b007b7/1349-7235-63-0271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/87ccacfc31be/1349-7235-63-0271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/bd52b9abc7f2/1349-7235-63-0271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/b8824d20399e/1349-7235-63-0271-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adc0/10864076/ad4609abe8a4/1349-7235-63-0271-g005.jpg

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