Drummond Robert J, Kunath Tilo, Mee P Joseph, Ross James A
Tissue Injury and Repair Group, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland EH16 4SB;
Exp Ther Med. 2011 Jan;2(1):3-7. doi: 10.3892/etm.2010.173. Epub 2010 Dec 2.
Although diabetes can be managed clinically with the use of insulin injections, it remains an incurable and inconvenient disorder. In the long-term, it is associated with a number of clinical complications, such as cardiovascular disease, resulting in a desire for the development of new methodologies to replace defective cells and provide a lasting normality without the need for drug treatment. Stem cells, including induced pluripotent stem cells, offer the possibility of generating cells suitable for transplantation due to their capacity to differentiate into all tissue lineages. However, many issues must be addressed before this type of treatment becomes a reality, including the need for a greater understanding of the underlying biology involved in the onset of diabetes.
尽管糖尿病可以通过注射胰岛素进行临床治疗，但它仍然是一种无法治愈且不便的疾病。从长远来看，它会引发许多临床并发症，如心血管疾病，这使得人们渴望开发新方法来替代有缺陷的细胞，并在无需药物治疗的情况下实现持久的正常状态。干细胞，包括诱导多能干细胞，因其能够分化为所有组织谱系，提供了生成适合移植细胞的可能性。然而，在这种治疗成为现实之前，必须解决许多问题，包括需要更深入地了解糖尿病发病背后的生物学机制。
