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Overexpression of a chromatin remodeling factor, RSF-1/HBXAP, correlates with aggressive oral squamous cell carcinoma.RSF-1/HBXAP 染色质重塑因子的过表达与侵袭性口腔鳞状细胞癌相关。
Am J Pathol. 2011 May;178(5):2407-15. doi: 10.1016/j.ajpath.2011.01.043.
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Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer.蛋白相互作用与 C 端激酶 1（PICK1）参与促进肿瘤生长，并与人乳腺癌的不良预后相关。
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The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1.人类蔗糖非发酵蛋白2同源物在Rsf-1的促肿瘤功能中的作用。
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Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma.一种染色质重塑基因Rsf-1在卵巢癌和乳腺癌中的表达。
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Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.染色质重塑基因Rsf-1/HBXAP在卵巢癌中的扩增。
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Gastric adenocarcinoma: review and considerations for future directions.胃腺癌：综述与未来方向的思考
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Non-Hodgkin lymphoma: an update.非霍奇金淋巴瘤：最新进展
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Functional analysis of the subunits of the chromatin assembly factor RSF.染色质组装因子RSF亚基的功能分析
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Gastric cancer.胃癌
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HBXAP, a novel PHD-finger protein, possesses transcription repression activity.HBXAP是一种新型的含植物同源结构域（PHD）的蛋白质，具有转录抑制活性。
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高RSF-1表达与胃腺癌患者的不良预后相关。

High RSF-1 expression correlates with poor prognosis in patients with gastric adenocarcinoma.

作者信息

Hu Ben-Shun, Yu Hai-Feng, Zhao Gao, Zha Tian-Zhou

机构信息

Department of General Surgery, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi 214000, China.

出版信息

Int J Clin Exp Pathol. 2012;5(7):668-73. Epub 2012 Sep 5.

PMID:22977663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438760/
Abstract

AIM

To investigate the expression and prognostic significance of RSF-1 in gastric adenocarcinoma.

METHODS

RSF-1 expression was analyzed using immunohistochemical staining on tissue samples from a consecutive series of 287 gastric adenocarcinoma patients who underwent tumor resections between 2003 and 2006.The relationship between RSF-1 expression, clinicopathological factors, and patient survival was investigated.

RESULTS

Immunohistochemical staining indicated that RSF-1 is highly expressed in 52.6% of gastric adenocarcinomas. RSF-1 expression levels were closely associated with tumor size, histological differentiation, tumor stage, and lymph node involvement. Kaplan-Meier survival analysis showed that high RSF-1 expression exhibited a significant correlation with poor prognosis for gastric adenocarcinoma patients. Multivariate analysis revealed that RSF-1 expression is an independent prognostic parameter for the overall survival rate of gastric adenocarcinoma patients.

CONCLUSION

Our data suggest that RSF-1 plays an important role in gastric adenocarcinoma progression and that high RSF-1 expression predicts an unfavorable prognosis in gastric adenocarcinoma patients.

摘要

目的

探讨RSF-1在胃腺癌中的表达及其预后意义。

方法

采用免疫组织化学染色法分析2003年至2006年间连续287例行肿瘤切除术的胃腺癌患者组织样本中RSF-1的表达情况。研究RSF-1表达与临床病理因素及患者生存之间的关系。

结果

免疫组织化学染色显示，52.6%的胃腺癌中RSF-1高表达。RSF-1表达水平与肿瘤大小、组织学分化、肿瘤分期及淋巴结受累密切相关。Kaplan-Meier生存分析表明，RSF-1高表达与胃腺癌患者预后不良显著相关。多因素分析显示，RSF-1表达是胃腺癌患者总生存率的独立预后参数。

结论

我们的数据表明，RSF-1在胃腺癌进展中起重要作用，RSF-1高表达预示胃腺癌患者预后不良。