NY Obesity Nutrition Research Center, St. Luke's - Roosevelt Hospital, New York, NY, USA.
Appetite. 2012 Dec;59(3):956-9. doi: 10.1016/j.appet.2012.08.025. Epub 2012 Sep 13.
Heightened cortisol response to stress due to hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis may stimulate appetite and food intake. In this study, we assessed cortisol responsivity to a cold pressor test (CPT) as well as appetite ratings and subsequent test meal intake (TMI) in obese women. Following an overnight fast on two counterbalanced days, 20 obese women immersed their non-dominant hand for 2min in ice water (CPT) or warm water (WW) as a control. Plasma cortisol (ng/ml), heart rate, and blood pressure, as well as ratings of stress, pain, and appetite, were serially acquired. An ad libitum liquid meal was offered at 45min and intake measured covertly. Fasting cortisol was higher at 15min (mean peak cortisol) following the CPT compared to WW. Higher stress was reported at 2 and 15min for the CPT compared to WW. Pain, an indirect marker of the acute stress, systolic and diastolic blood pressure increased following the CPT at 2min compared to WW. Hunger decreased after the CPT at 2 and 15min, and desire to eat ratings were lower following CPT compared to WW. Subjects did not have greater test meal intake (TMI) following CPT compared to WW. There was also no significant relationship between cortisol levels following stress and TMI, indicating that cortisol did not predict subsequent intake in obese women.
由于下丘脑-垂体-肾上腺（HPA）轴的过度活跃，导致应激时皮质醇反应增强，可能会刺激食欲和食物摄入。在这项研究中，我们评估了肥胖女性在冷加压试验（CPT）中的皮质醇反应以及食欲评分和随后的测试餐摄入（TMI）。在两个平衡日的一个夜间禁食后，20 名肥胖女性将非优势手浸入冰水（CPT）或温水（WW）中 2 分钟，作为对照。连续采集血浆皮质醇（ng/ml）、心率和血压以及应激、疼痛和食欲评分。在 45 分钟时提供一份随意的液体餐，并秘密测量摄入量。与 WW 相比，CPT 后 15 分钟时（平均峰值皮质醇）的空腹皮质醇更高。与 WW 相比，CPT 时在 2 和 15 分钟时报告的压力更高。疼痛是急性应激的间接标志物，与 WW 相比，CPT 后 2 分钟时收缩压和舒张压升高。CPT 后 2 和 15 分钟时饥饿感下降，CPT 后食欲评分低于 WW。与 WW 相比，CPT 后测试餐摄入（TMI）没有增加。压力后皮质醇水平与 TMI 之间也没有显著关系，表明皮质醇不能预测肥胖女性随后的摄入量。
